Analysis of genetic alterations identifies the frequent mutation of GNAS in colorectal laterally spreading tumors  

作　　者：Lei Pan Junsheng Chen Chaojun Zhu Lu Han Aimin Li Side Liu 

机构地区：[1]Guangdong Provincial Key Laboratory of Gastroenterology,Department of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,P.R.China

出　　处：《Cancer Communications》2020年第11期636-640,共5页癌症通讯（英文）

基　　金：This research was mainly supported by grants from the National Nature Science Funds of China(grant no.81772964),the Special Scientific Research Fund of Public Welfare Profession of National Health and Family Plan-ning Commission(grant no.201502026)and the Guang-dong Gastrointestinal Disease Research Center(grant no.2017B020209003).

摘　　要：Dear Editor,Colorectal cancer(CRC)is among the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide[1].Most CRCs develop from adenomas.Laterally spreading tumors(LSTs)are non-polypoid superficial colorectal neoplasms(CRNs)that are larger than 1 cm and typically extend laterally along the luminal wall.Based on surface morphology,it can be classified into a granular or nongranular type.The pathological morphology of LST manifests only as adenoma or with cancer.Recent studies have characterized 45-79%of LSTs as high-grade intraepithelial neoplasia(HGIN)or submucosal invasion;and the risk of submucosal invasion increases with lesion size[2].Hence,LST is considered a precancerous CRC lesion.Patients with LSTs are usually asymptomatic and diagnosis typically occurs during physical examinations or screening colonoscopy.

关 键 词：INVASION COLORECTAL alterations 

分 类 号：R73[医药卫生—肿瘤]