响应面法优化茯苓超微粉碎工艺的研究  

Optimization of Ultrafine Comminution Process for Poria cocos by Response Surface Methodology

作　　者：蔡丹凤[1] 吴长辉 唐闽杰 朱忠敏 陈丹红 CAI Dan-Feng;WU Chang-Hui;TANG Min-Jie;ZHU Zhong-Min;CHEN Dan-Hong(Fujian Health College,Fuzhou 350101 Fujian,China;Fujian Xianzhilou Biotechnology Co.Ltd.,Fuzhou 350002 Fujian,China;Fujian Testing Technology Institute,Fuzhou 350001 Fujian,China)

机构地区：[1]福建卫生职业技术学院,福建福州350101 [2]福建仙芝楼生物科技有限公司,福建福州350002 [3]福建省测试技术研究所,福建福州350001

出　　处：《广州中医药大学学报》2021年第7期1467-1471,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：福建省科技厅省属公益类科研院所专项(编号:2018R1007-3)。

摘　　要：【目的】探究茯苓超微粉碎适宜的工艺技术参数。【方法】应用振动磨超微粉碎技术制备茯苓超微粉。以茯苓微粉平均粒径(D50)作为评价指标,在单因素实验的基础上,观察投料量、含水量及粉碎时间对微粉D50的影响,并采用响应面法优化超微粉碎工艺技术参数。【结果】茯苓微粉制备的最适工艺参数:投料量为200 g,原料含水量为5.3%,粉碎时间为32 min,预测D50为21.23μm,验证D50为(21.46±0.51)μm。【结论】工艺参数条件与茯苓微粉粒径的相关性良好,响应面法对茯苓超微粉碎工艺具有较好的指导意义。Objective To explore the appropriate process parameters of the ultrafine comminution for Poria cocos.Methods An ultrafine comminution process was applied for preparing the submicron powder of Poria cocos by vibratory mill.Using average particle diameter(D50)of Poria cocos submicron powder as evaluation index,we observed the effects of material input,water content and milling time on superfine D50 based on single factor experimental design,and applied the response surface methodology to optimize the process parameters of the ultrafine comminution for Poria cocos.Results The most appropriate process parameters for Poria cocos submicron powder were as follows:material input was 200 grams,water content was 5.3%,and milling time was 32 minutes.The predicted D50 value was 21.23μm,ultimately D50 value was identified as(21.46±0.51)μm.Conclusion There is good correlation between conditions of process parameters and diameter of Poria cocos submicron powder particles,and there is a better guiding significance for Poria cocos ultrafine comminution process by using response surface methodology.

关 键 词：茯苓 超微粉碎 响应面法 工艺优化 

分 类 号：R284.2[医药卫生—中药学]