乳酸催化的酰胺与胺的氨解反应  

Lactic Acid-Catalyzed Transamidation Reactions of Carboxamides with Amines

作　　者：刘巨艳 赵聪颖 Liu Juyan;Zhao Congying(Tianjin Key Laboratory of Structure and Performance for Functional Molecules,College of Chemistry,Tianjin Normal University,Tianjin 300387)

机构地区：[1]天津师范大学化学学院天津市功能分子结构与性能重点实验室,天津300387

出　　处：《有机化学》2021年第6期2310-2318,共9页Chinese Journal of Organic Chemistry

基　　金：天津市自然科学基金(No.12JCZDJC34300);大学生创业训练(No.201447)资助项目。

摘　　要：发展了一种对环境友好的乳酸促进的酰胺与胺的氨解的新方法,该方法能够成功合成一系列芳香、脂肪类酰胺和脲的衍生物.该方法最显著的特征是催化剂廉价易得、无挥发性溶剂、底物转化率高及产物提纯操作简单.An environmentally benign protocol for the transamidation of carboxamides with amines using lactic acid as a green catalyst has been developed.The method has been successfully applied to the synthesis of a wide range of aromatic and aliphatic amides and ureas.The reaction has the advantages of the ready accessibility of the catalyst,solvent-free condition,efficient transformation and green processing.

关 键 词：乳酸 酰胺 脲 氨解 

分 类 号：O622.6[理学—有机化学]