慢性心力衰竭与外周血白细胞端粒长度的相关性  

Association Between Telomere Length of Peripheral Blood Leukocytes and Chronic Heart Failure

作　　者：张秀丽[1] 吴智业[1] 王秋实 缪绯[1] 李和慨 陈敏生[1] ZHANG Xiu-li;WU Zhi-ye;WANG Qiu-shi;MIAO Fei;LI He-kai;CHEN Min-sheng(Department of Cardiology//Laboratory of Heart Center,Zhujiang Hospital,Southern Medical University,Guangzhou 510280,China;Department of Cardiology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]南方医科大学珠江医院心内科//珠江医院心脏中心实验室,广东广州510280 [2]首都医科大学附属北京友谊医院心内科,北京100050

出　　处：《中山大学学报（医学科学版）》2021年第4期557-562,共6页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(82000460)。

摘　　要：【目的】探讨外周血白细胞端粒长度与慢性心力衰竭(CHF)发生风险的相关性。【方法】本研究招募了224例患者,根据左心室射血分数分为非CHF(Non-CHF)组(117例)和CHF组(107例),用实时荧光定量多聚核苷酸链式反应(qPCR)进行外周血白细胞端粒长度的测量。比较Non-CHF组和CHF组患者端粒长度,并采用二元Logistic回归模型分析端粒长度与CHF发生风险是否相关。【结果】Non-CHF组和CHF组患者外周血白细胞端粒相对长度分别为0.9(0.64~1.18)、0.7(0.53~0.89),CHF组患者的端粒长度比Non-CHF组患者缩短,差异有统计学意义(P<0.001),且端粒长度与CHF发生风险相关[OR=0.17,95%CI为(0.07,0.40),P<0.05]。在调整了混杂因素后,端粒长度仍与CHF发生风险相关[OR=0.14,95%CI为(0.05,0.33),P<0.05]。【结论】研究结果显示外周血白细胞端粒长度与CHF发生风险独立相关。【Objective】To explore the association between telomere length of leukocytes and chronic heart failure(CHF).【Methods】A total of 224 patients were recruited in this study.The patients were divided into non-CHF(Non-CHF)group(involving 117 patients)and CHF group(involving 107 patients)according to left ventricular ejection fraction.Telomere length of peripheral blood leukocytes was measured by real-time fluorescence quantitative polynucleotide chain reaction(qPCR).Telomere length of leukocytes was compared between Non-CHF group and CHF group.Binary Logistic regression model was used to analyze the association between telomere length and CHF.【Results】Telomere length in Non-CHF patients and CHF patients was 0.9(0.64~1.18),0.7(0.53~0.89),respectively.Telomere length was shorter in CHF patients than in Non-CHF patients(P<0.001).Further results showed that telomere length was associated with CHF[OR=0.17,95%CI was(0.07,0.40),P<0.05].After adjusting confounding factors,telomere length was still associated with CHF[OR=0.14,95%CI was(0.05,0.33),P<0.05].【Conclusion】The results show that telomere length of peripheral blood leukocytes is independently associated with CHF.

关 键 词：白细胞 端粒 端粒长度 慢性心力衰竭 

分 类 号：R364[医药卫生—病理学]