经颅磁刺激联合奥拉西坦改善脑卒中患者认知障碍的研究  

Transcranial magnetic stimulation combined with oxiracetam improves cognitive impairment in CIS patients

作　　者：张光宇[1] 李果[1] 杨珊[1] Zhang Guangyu;Li Guo;Yang Shan(Rehabilitation Research Center,Chongqing Three Gorges Medical College Public Health Management School,Chongqing 404120,China)

机构地区：[1]重庆三峡医药高等专科学校康复教研室,404120

出　　处：《中华老年心脑血管病杂志》2021年第7期735-737,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的分析经颅磁刺激(TMS)联合奥拉西坦改善脑卒中患者轻度认知功能障碍的临床效果。方法选择本校附属医院收治的96例脑卒中患者,分为TMS组(32例)、联合组(30例)和对照组(34例)。对照组进行常规治疗,TMS组采用TMS治疗,联合组同时给予奥拉西坦与TMS治疗。每个疗程为4周,各组均治疗3个疗程。比较患者治疗前后的蒙特利尔认知评估量表(MoCA)评分,观察各组患者脑水肿体积变化,同时对比各组患者治疗有效率。结果治疗后各组MoCA评分均有所改善,且联合组高于TMS组和对照组,差异有统计学意义(P<0.05)。治疗后各组患者的相对脑水肿和绝对脑水肿体积均有所减小,联合组脑水肿改善情况优于对照组和TMS组,差异有统计学意义(P<0.05)。对照组治疗有效率为61.76%,TMS组治疗有效率为75.00%,联合组治疗有效率为96.67%,联合组治疗有效率优于TMS组与对照组,差异有统计学意义(P<0.05)。结论TMS联合奥拉西坦治疗可改善脑卒中患者的轻度认知功能障碍,为该类患者提供了有效的临床治疗手段。Objective To analyze the clinical effect of transcranial magnetic stimulation(TMS)combined with oxiracetam on MCI in cerebral ischemic stroke(CIS)patients.Methods Ninetysix CIS patients admitted to the affiliated hospital of our school were randomly divided into TMS group(n=32),TMS combined with oxiracetam group(n=30)and control group(n=34).The patients in control group received conventional treatment,those in TMS group received TMS treatment and those in TMS combined with oxiracetam group underwent both oxiracetam treatment and TMS treatment for 3 courses of treatment(4 weeks a course of treatment).The MoCA scale scores of different groups were compared before and after treatment.The change of brain edema volume and the efficiency of treatment in different groups were compared.Results The MoCA scale scores of different groups were improved and significantly higher in TMS combined with oxiracetam group than in TMS group and control group after treatment(P<0.05).The relative brain edema volume and absolute brain edema volume were reduced in different groups after treatment.The brain edema volume was significantly smaller in TMS combined with oxiracetam group than in control group and TMS group(P<0.05).The effective rate of treatment was 61.76%in control group,75.00%in TMS group,96.67%in TMS combined with oxiracetam group and was significantly higher in TMS combined with oxiracetam group than in TMS group and control group(P<0.05).Conclusion TMS combined with oxiracetam can improve MCI in CIS patients and can thus provide an effective clinical treatment for such patients.

关 键 词：经颅磁刺激 卒中 认知功能障碍 脑水肿 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.1[医药卫生—临床医学]