缺血性中风后血管生成及针刺作用的研究进展  

Research Progress on Angiogenesis and Acupuncture after Ischemic Stroke

作　　者：麻聪聪 王东岩[2] 路思宇 杨海永 MA Congcong;WANG Dongyan;LU Siyu;YANG Haiyong(Heilongjiang University of Chinese Medicine,Harbin 150001,Heilongjiang,China;Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,Heilongjiang,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150001 [2]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150001

出　　处：《辽宁中医杂志》2021年第5期201-205,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81473763);黑龙江省自然科学基金联合引导项目(LH2019H113);黑龙江中医药大学创新团队建设项目(2017sit01)。

摘　　要：中风是全世界导致死亡和残疾的主要原因,缺血性中风是中风的主要亚型,及时恢复或改善局部脑血供对改善中风结局和中风后功能恢复至关重要。缺血性中风的恢复很大程度上依赖于通过血管生成适当地恢复血流,新形成的血管可以增加脑血流,从而增加输送到受影响脑组织的氧气和营养物质的量。血管生成受到中枢神经系统中许多关键血管生成因子的严格控制。研究表明,针刺可以通过调节VEGF、HIF-1、bFGF和Ang-2等血管生成调控因子促进血管新生,通过以血管生成因子为靶点的各种途径促进血管生成是治疗实验性缺血性中风的有效方法。该文综述了中风后脑血管生成相关基因表达的研究,以及针刺在中风后血管生成中的作用研究进展。Stroke is the main cause of death and disability world-widely.Ischemic stroke is the main sub-type of stroke.Timely recovery or improvement of local cerebral blood supply is essential to improve the outcome of stroke and functional recovery after stroke.The recovery of ischemic stroke largely depends on the proper recovery of blood flow through angiogenesis.The newly formed blood vessels can increase cerebral blood flow, thereby increasing the amount of oxygen and nutrients transported to the affected brain tissue.Angiogenesis is strictly controlled by many key angiogenic factors in the central nervous system.Studies have shown that acupuncture can promote angiogenesis by regulating angiogenesis regulatory factors such as vascular endothelial growth factor, HIF-1,bFGF and Ang-2.It is an effective method to treat experimental ischemic stroke by promoting angiogenesis through various ways targeting angiogenesis factors.This paper reviewed the research progress of gene expression related to cerebral angiogenesis after stroke and the role of acupuncture in angiogenesis after stroke.

关 键 词：缺血性中风 血管生成 针刺 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]