自拟芪藤通络方内服加红艾汤外用对奥沙利铂导致周围神经毒性的影响  

Effect of Oral Administration of Qiteng Tongluo Formula(芪藤通络方)Combined with Hong'ai Decoction(红艾汤)External Bath on Oxaliplatin-Induced Peripheral Neuropathy

作　　者：潘传芳[1] 姚琼[1] 祝利民[1] 沈克平[1] PAN Chuanfang;YAO Qiong;ZHU Limin;SHEN Keping(Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院肿瘤科,上海200032

出　　处：《辽宁中医杂志》2021年第6期140-142,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：第六批全国老中医药专家学术经验继承工作项目[国中医药人教发(2017)29号]。

摘　　要：目的观察芪藤通络方加减内服联合红艾汤外用对奥沙利铂导致的周围神经毒性的疗效。方法将100例符合纳入标准的化疗后周围神经毒性患者随机分为两组,治疗组采用芪藤通络方加减内服加红艾汤外洗,对照组采用甲钴胺口服,比较治疗前后的两组中医症状积分、周围神经毒性改善情况及周围神经传导速度。结果治疗组和对照组治疗后较治疗前中医症状积分均有改善(P<0.05),治疗组治疗后的中医症状积分(4.02±0.68)分,低于对照组(10.93±1.02)分,两组比较差异具有统计学意义(P<0.05)。对周围神经损伤治疗的总有效率治疗组高于对照组。经过4周治疗后,治疗组与对照组的正中神经和腓总神经感觉神经传导速度(sensory nerve conduction velocity,SNCV)和运动神经传导速度(motor nerveconduction velocity,MNCV)均较治疗前改善,与治疗前比较均具有统计学意义(P<0.05)。治疗组治疗后的SNCV和MNCV均快于对照组,两者之间差异具有统计学意义(P<0.05)。结论芪藤通络方加减内服加红艾汤外用对奥沙利铂导致神经毒性的疗效由于甲钴胺。Objective To observe the clinical effect of oral administration of Qiteng Tongluo Formula(芪藤通络方) combined with Hong′ai Decoction(红艾汤)external bath on oxaliplatin-induced peripheral neuropathy.Methods A total of 100 oxaliplatin-induced peripheral neuropathy patients were divided by random number table method into two groups.The control group received oral administration of Qiteng Tongluo Formula combined with Hong′ai Decoction external bath every day.After 4 weeks of treatment,the patients′ symptom scores in traditional Chinese medicine and peripheral nerve injury grades in two groups were observed and total effective rates were calculated.The peripheral nerve conductive velocities between the two groups were compared.Results The study was completed in 95 patients.After treatment,symptom scores of numbness of the extremities,pain,inconvenient flexion and mental fatigue of the treatment group after treatment were significantly lower than those of the control group(P<0.05).The total effective rate of treatment for peripheral nerve injury in the treatment group was also higher than that in the control group(P<0.05).Sensory nerve conduction velocity(SNCV)and motor nerve conduction velocity(MNCV) of median nerves and common peroneal nerves after treatment were all significantly faster than those before treatment(all P<0.05).And those were faster in the treatment group after treatment(P<0.05).Conclusion The therapeutic effect of oral administration of Qiteng Tongluo Formula combined with Hong′ai Decoction external bath on oxaliplatin-induced peripheral neuropathy is better than that of methylcobalamin.

关 键 词：奥沙利铂 周围神经毒性 中药 

分 类 号：R745[医药卫生—神经病学与精神病学]