数据库研究第十部分:结直肠癌的辅助治疗特征分析  

Database research partⅩ:feature analysis of adjuvant treatment of colorectal cancer

作　　者：刘勇[1] 汪晓东[1] 朱佳怡 李立[1] 周总光[1] LIU Yong;WANG Xiaodong;ZHU Jiayi;LI Li;ZHOU Zongguang(Department of Gastrointestinal Surgery,West China Hospital of Sichuan University,Chengdu 610041,P.R.China;West China School of Nursing,Sichuan University,Chengdu 610041,P.R.China)

机构地区：[1]四川大学华西医院胃肠外科,成都610041 [2]四川大学华西护理学院,成都610041

出　　处：《中国普外基础与临床杂志》2021年第7期937-944,共8页Chinese Journal of Bases and Clinics In General Surgery

基　　金：四川大学华西医院临床研究孵化项目(项目编号:2021HXFH052)。

摘　　要：目的分析华西肠癌数据库(Database from Colorectal Cancer,DACCA)中结直肠癌的辅助治疗特征。方法对DACCA数据库中的信息进行筛选,包括辅助治疗(辅助策略、依从性)、辅助化疗(指征选择、接受度、实际化疗周期数、效果、规范化应用)、辅助放疗(指征选择、接受度和效果)及靶向治疗(口服靶向药物的使用、静脉靶向药物的使用),选择其中必须至少1项条件不为“空”的条目。结果本次研究最终获得符合筛选条件的数据3955条。(1)辅助治疗的辅助策略选择和依从性情况,选择“辅助治疗”及“配合”的数据构成比最高,分别为35.6%(929/2611)和28.1%(664/2362)。(2)辅助化疗的“指征选择”“接受度”“实际化疗周期数”“效果”“规范化应用”中数据构成比最高的分别是“必须”(38.6%,1140/2963)、“拒绝”53.1%(1373/2586)、6周期辅助化疗(12.4%,338/2722)、“稳定”(59.9%,618/1031)、“规范化应用”(78.6%,903/1149)。具备辅助化疗指征与最终接受化疗之间有明确的关系(χ^(2)=505.262,P<0.001),当辅助化疗评估指征为可选时,最终选择拒绝的占比很高(89.0%,137/154)。(3)辅助放疗的“指征选择”“接受度”和“效果”中数据构成比最高的分别是“无须”(49.1%,1432/2915)、“拒绝”(93.8%,2629/2803)、“稳定”(38.1%,45/118)。具备辅助放疗指征与最终接受放疗之间有关(χ^(2)=139.593,P<0.001),即应该放疗者其接受度并不高(10.6%,127/1194),可选放疗者全部拒绝了放疗(100%)。(4)靶向治疗中口服和静脉靶向药物选择“无”的数据构成比最高,分别为84.2%(2121/2520)、73.3%(206/281)。结论通过对目前华西DACCA数据库中结直肠癌辅助治疗阶段真实世界数据的展示,为利用大数据决策预后提供一些参考依据。Objective To analyze the characteristics of adjuvant treatment of colorectal cancer in the Database from Colorectal Cancer(DACCA).Methods The informations in the DACCA database were screened,including adjuvant therapy(adjuvant strategy,compliance),adjuvant chemotherapy(indication selection,acceptance,actual cycles of chemotherapy,effect,and standardized application),adjuvant radiotherapy(indication selection,acceptance,and effect),and targeted therapy(uses of oral and intravenous targeted drugs).The data that at least one of items must not be“empty”were selected.Results A total of 3955 data items were analyzed for colorectal cancer adjuvant therapy.(1)The highest data composition ratio of“planned strategy of adjuvant therapy”and“compliance of adjuvant therapy”was“adjuvant therapy”(35.6%,929/2611)and“coordination”(28.1%,664/2362),respectively.(2)The highest data composition ratios of“indication of chemotherapy”,“acceptance of chemotherapy”,“cycles of chemotherapy”,“effect of chemotherapy”,and“chemotherapy based guidelines”were“must”(38.6%,1140/2963),“rejection”(53.1%,1373/2586),“6-cycle adjuvant chemotherapy”(12.4%,338/2722),“stability”(59.9%,618/1031),and“standardization”(78.6%,903/1149).There was an obvious relationship between the planned strategy of adjuvant chemotherapy and the final acceptance of chemotherapy(χ^(2)=505.262,P<0.001),that was,when the planned strategy of adjuvant chemotherapy was“optional”,the proportion of final rejection was very high(89.0%,137/154).(3)The highest data composition ratios of“indication of radiation”,“acceptance of radiation”,and“effect of radiation”were“unnecessary”(49.1%,1423/2915),“rejection”(93.8%,2629/2803),and“stability”(38.1%,45/118).There was a correlation between the planned strategy of adjuvant radiotherapy and the final acceptance of radiotherapy(χ^(2)=139.593,P<0.001),that was,when the patients who should receive radiotherapy had not high acceptance(10.6%,127/1194),and the pat

关 键 词：结直肠癌 数据库 大数据 辅助治疗 疗效 

分 类 号：R735.34[医药卫生—肿瘤]