CRH Neurons in the Laterodorsal Tegmentum Mediate Acute Stress-induced Anxiety  

作　　者：Wenqi Tang Danqing Zhou Siyu Wang Sijia Hao Xiaomeng Wang Mohamed Helmy Junming Zhu Hao Wang 

机构地区：[1]Department of Neurobiology and Department of Neurosurgery of Second Affiliated Hospital,Key Laboratory for Biomedical Engineering of the Ministry of Education,Zhejiang University School of Medicine,Hangzhou 310058,China [2]NHC and CAMS Key Laboratory of Medical Neurobiology,MOE Frontier Science Center for Brain Research and Brain Machine Integration,School of Brain Science and Brain Medicine,Zhejiang University,Hangzhou 310058,China [3]Department of Neurosurgery,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China [4]Children’s Hospital,Zhejiang University School of Medicine,Hangzhou 310052,China

出　　处：《Neuroscience Bulletin》2021年第7期999-1004,共6页神经科学通报（英文版）

基　　金：the National Natural Science Foundation of China(31970940,31671100,31622027,and 31671100);the Zhejiang Provincial Natural Science Foundation of China(LR18H090001);the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2018PT31041);the Program for Introducing Talents in Discipline to Universities,and the Fundamental Research Funds for Central Universities(2019QNA5001).

摘　　要：Dear Editor,Acute stress-induced anxiety is pervasive in both animals and humans.The natural stress response effectively helps animals to maintain arousal,flee from danger,or simply stay alert to their surroundings.On the other hand,excessive anxiety is strongly associated with many severe psychiatric disorders such as depression,phobia,and posttraumatic stress disorder(PTSD).Although the probability of an individual suffering clinical anxiety reaches an average of 28%during their lifetime,the underlying neural mechanisms of anxiety remain poorly understood.

关 键 词：Acute MAINTAIN lifetime 

分 类 号：R74[医药卫生—神经病学与精神病学]