神经内镜经鼻蝶切除无功能性垂体腺瘤术后复发的相关因素分析  

Analysis of factors related to recurrence of nonfunctional pituitary adenoma after neuroendoscopic transsphenoidal resection

作　　者：谢微嫣 刘春晖 李储忠[1] 李振业[1] 朱海波 方秋月 张亚卓[1] Xie Weiyan;Liu Chunhui;Li Chuzhong;Li Zhenye;Zhu Haibo;Fang Qiuyue;Zhang Yazhuo(Cell Biology Room,Beijing Neurosurgical Institute,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学,北京市神经外科研究所细胞生物室,100070

出　　处：《中国微侵袭神经外科杂志》2021年第6期241-244,共4页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：国家自然科学基金(编号:81672495)。

摘　　要：目的探讨神经内镜经鼻蝶手术切除无功能性垂体腺瘤(nonfunctioning pituitary adenoma,NFPA)术后复发的相关因素分析。方法回顾性183例神经内镜下经鼻蝶手术切除的NFPA病例资料,病人术后3、6、12个月均行MRI增强检查,然后每年复查一次。结果术后随访7~9年,46例肿瘤复发,复发时间为3~91个月,平均(38.15±23.87)个月。年龄、手术切除程度、肿瘤最长径、侵袭与否是影响NFPA术后复发的独立危险因素(均P<0.05)。结论评估并识别NFPA术后复发的高危因素,对选择治疗方式及预测病人预后具有重要临床价值,可以早期发现复发并制定对病人更为有利的治疗方案。Objective To investigate the factors related to the recurrence of nonfunctional pituitary adenoma(NFPA)after neuroendoscopic transnasal sphenoidal surgery.Methods The clinical data of 183 patients with NFPA undergoing neuroendoscopic transsphenoidal resection were retrospectively analyzed.The enhanced MRI examinations were performed 3,6,12 months after the operation,and then reviewed once a year.Results After 7-9 years of follow-up,46 tumors recurred.The recurrence time was 3 to 91 months,with an average time of(38.15±23.87)months.Age,extent of surgical resection,tumor longest diameter,and invasion were independent risk factors for NFPA recurrence(all P<0.05).Conclusions To evaluate and identify the high-risk factors for postoperative recurrence of NFPA is of great clinical value for the selection of surgical methods and the prediction of prognosis of patients,and helpful in detecting recurrence early and develop a more optimized treatment plan.

关 键 词：神经内镜 垂体腺瘤 无功能性 入路 经鼻蝶 复发 

分 类 号：R736.4[医药卫生—肿瘤]