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作 者:Zhengfu Zhang Ying Guo Lingwei Zhang Jianbin Zhang Xionghui Wei
机构地区:[1]Department of Applied Chemistry,College of Chemistry&Molecular Engineering,Peking University,Beijing 100871,China [2]Center for Drug Certification,State Food and Drug Administration,Beijing 100061,China [3]Department of Chemical Biology,School of Pharmaceutical Sciences,Peking University,Beijing 100083,China
出 处:《Acta Pharmaceutica Sinica B》2012年第5期464-471,共8页药学学报(英文版)
基 金:This work was supported by grant 20080430283 from the China Postdoctoral Science Foundation and Jiangxi Yongfeng Boyuan Industry Co.,Ltd.(Jiangxi,China).
摘 要:This study aimed to investigate the ability of chelerythrine chloride(CHE),the main active ingredient of Macleaya cordata,to induce apoptosis in human gastric cancer BGC-823 cells.The results demonstrate that CHE inhibits cell proliferation in a time-and dose-dependent manner with accompanying S phase arrest.It also induces apoptosis by a mechanism involving a reduction in the mitochondrial mem brane potential,the release of cytochrome c,activation of caspase 3 and cleavage of poly-ADP-ribose polymerase.In addition,CHE-induced apoptosis is accompanied by down-regulation of Bcl-x1 and Bcl-2 proteins with no change in the levels of Bax proteins.Taken together,the results support the development of CHE as a potentially useful anticancer drug for the treatment of gastric cancer.
关 键 词:Macleaya cordata Chelerythrine chloride BGC-823 cells APOPTOSIS
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