The role of fatty acid metabolism and lipotoxicity in pancreatic β-cell injury:Identification of potential therapeutic targets  

作　　者：Haopeng Yang Xuejun Li 

机构地区：[1]Department of Pharmacology,School of Basic Medical Sciences,Peking University,Beijing 100191,China

出　　处：《Acta Pharmaceutica Sinica B》2012年第4期396-402,共7页药学学报（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.91129727,81020108031,and 30973558);the Major Specialized Research Fund from the Ministry of Science and Technology in China(No.2009ZX09103-144).

摘　　要：Over the last 20 years,intensive research has been focused on the specific mechanisms mediating the pancreatic β-cell injury.Both the decreased viability and the dysfunction of β-cells have become the key factors in the development of dia betes mellitus.Thus,it is of utmost importance to elucidate the discrete pathological changes in pancreatic β-cells within the context of the various lipotoxicity models.The goal of these studies is to generate evidence to improve not only the clinical treatment for dia betics,but also modulate the diet and activities of groups at high risk for diabetes.In this regard,we review the role of lipotoxicity in pancreatic β-cell injury and identify potential therapeutic targets in this cell model.

关 键 词：LIPOTOXICITY Pancreaticβ-cells Insulin biosynthesis Insulin secretion AQUAPORIN 

分 类 号：R73[医药卫生—肿瘤]