Analysis of the bioactive components from different growth stages of Fritillaria taipaiensis P. Y. Li  

作　　者：Rui Peng Peng Ma Rangyu Mo Nianxi Sun 

机构地区：[1]Chongqing Academy of Chinese Materia Medica,Chongqing 400065,China

出　　处：《Acta Pharmaceutica Sinica B》2013年第3期167-173,共7页药学学报（英文版）

基　　金：support from the Natural Science Foundation of Chongqing Municipality,China(CSTC,2011BA 5034);funded by the Chongqing Municipal Health Bureau,China(No.2009-1-12).

摘　　要：High-performance liquid chromatography(HPLC)coupled with an evaporative light scattering detector(ELSD)or a diode array detector(DAD)were utilized for the quantitative analysis of 4 alkaloids(peimisine,sipeimine,peimine and peiminine)and 9 nucleosides and nucleobases(uracil,uridine,adenosine,adenine,inosine,thymine,cytidine,guanosine and thymidine)from Fritillaria taipaiensis P.Y.Li that had been cultivated in the same field for 2–6 years.The content of peimisine,sipeimine,peimine,peiminine,uracil,thymine,adenine and inosine in plants cultivated for 2–4 years was significantly higher than that of plants cultivated for 5–6 years,while the content of cytidine,uridine,guanosine,thymidine and adenosine did not change over this period.This is the first evaluation of variation in the bioactive compounds in F.taipaiensis over its life cycle.

关 键 词：Fritillaria taipaiensis P.Y.Li HPLC ELSD DAD Alkaloid NUCLEOSIDE NUCLEOBASE Quality control 

分 类 号：O62[理学—有机化学]