Biomimetic synthesis of active stilbenolignan derivatives by oxidative coupling and acid-catalyzed polymerization  

作　　者：Chunsuo Yao Mao Lin Qingyun Yang 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Key Laboratory of Bioactive Substancesand Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

出　　处：《Acta Pharmaceutica Sinica B》2013年第2期102-108,共7页药学学报（英文版）

摘　　要：Two new stilbenolignans and one novel lactone stilbenolignan with a seven-membered ring were biomimetically synthesized by an oxidative coupling reaction and acid-catalyzed polymerization with either isorhapontigenin and ferulic acid or sinapinic acid,respectively,as the starting materials.The structures of the stilbenolignans were defined using spectral analysis and their mechanisms of formation are discussed.Anti-oxidant and anti-inflammatory activities of the novel stilbenolignans were tested,and the lactone stilbenolignan was observed to exhibit potent anti-oxidant activity.

关 键 词：Stilbenolignan ISORHAPONTIGENIN Oxidative coupling reaction Anti-oxidation activity Biomimetic synthesis 

分 类 号：O62[理学—有机化学]