ISORHAPONTIGENIN

作品数：7被引量：13H指数：2
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相关领域：医药卫生更多>>
相关作者：刘耕陶梁宇光林茂方亚南王爱兵更多>>
相关机构：北京协和医学院中国医学科学院北京协和医学院军事医学科学院更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《Chinese Chemical Letters》《Acta Pharmaceutica Sinica B》《中国药理学与毒理学杂志》更多>>
相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划更多>>
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Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression被引量：10
《Acta Pharmaceutica Sinica B》2021年第3期680-693,共14页Panxia Wang Minghui Wang Yuehuai Hu Jianxing Chen Yanjun Cao Cui Liu Zhongkai Wu Juan Shen Jing Lu Peiqing Liu 
supported by grants from the National Natural Science Foundation of China (81872860, 81803521, 81673433);National Major Special Projects for the Creation and Manufacture of New Drugs (2019ZX09301104, China);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2017BT01Y093, China);National Engineering and Technology Research Center for New drug Druggability Evaluation(Seed Program of Guangdong Province, 2017B090903004,China);Natural Science Foundation of Guangdong Province(2019A1515010273, China);Foundation from Guangdong Traditional Medicine Bureau (20191060, China);Fundamental Research Funds for the Central Universities (19ykpy131, China);Research and Industrialization team of Taxus chinensis var.mairel (2014YT02S044, China)。
As an effective anticancer drug, the clinical limitation of doxorubicin(Dox) is the time-and dose-dependent cardiotoxicity. Yes-associated protein 1(YAP1) interacts with transcription factor TEA domain 1(TEAD1) and pl...
关键词：ISORHAPONTIGENIN YAP1 DOXORUBICIN CARDIOTOXICITY Cardiomyocytes apoptosis TEAD1 Connective tissue growth factor AMPHIREGULIN 
Isorhapontigenin(ISO) induces autophagy and cell growth inhibition by upregulation of SESN2/Sestrin2 in the Jun N-terminal kinase/AP-1 dependent mannerin human bladder cancer cells
《中国药理学与毒理学杂志》2016年第10期1085-1086,共2页LIANG Yu-guang ZHU Jun-lan HUANG Hai-shan XIANG Dai-min ZHANG Dong-yun LI Jing-xia WANG Yu-lei JIN Hong-lei JIANG Guo-song HUANG Chuan-shu LIU Ze-yuan 
OBJECTIVE To investigate the machenism that isorhapontigenin(ISO)induced autophagy and cell growth inhibition in human bladder cancer cells on the basis of the existing research results,for providing a new mechanistic...
关键词：ISORHAPONTIGENIN bladder cancer AUTOPHAGY Sestrin2 JNK 
Biomimetic synthesis of active stilbenolignan derivatives by oxidative coupling and acid-catalyzed polymerization
《Acta Pharmaceutica Sinica B》2013年第2期102-108,共7页Chunsuo Yao Mao Lin Qingyun Yang 
Two new stilbenolignans and one novel lactone stilbenolignan with a seven-membered ring were biomimetically synthesized by an oxidative coupling reaction and acid-catalyzed polymerization with either isorhapontigenin ...
关键词：Stilbenolignan ISORHAPONTIGENIN Oxidative coupling reaction Anti-oxidation activity Biomimetic synthesis 
Inhibitory Effect of Isorhapontigenin on Copper-Mediated Peroxidation of Human Low-Density Lipoprotein in vitro
《Journal of Chinese Pharmaceutical Sciences》2004年第1期63-67,共5页方亚南 林茂 刘耕陶 
Aim To study the effect of Isorhapontigenin (Iso) on copper-mediatedperoxidation of human low-density lipoprotein (LDL) and on the toxicity of oxidized LDL (ox-LDL) tomouse macrophages in vitro. Methods Human LDL from...
关键词：ISORHAPONTIGENIN low-density lipoprotein oxidized low-density lipoprotein MACROPHAGES PHAGOCYTOSIS mitochondrial membrane potential 
Gnetuhainin P, a New Isorhapontigenin Dimer from the Lianas of Gnetum hainanense被引量：2
《Chinese Chemical Letters》2000年第12期1061-1062,共2页Ying Hong WANG Kai Sheng HUANG Mao LIN 
Gnetuhainin P, a new isorhapontigenin dimer, was isolated from the Lianas of Gnetum hainanense C. Y. Cheng. Its structure was established on the basis of spectroscopic evidence, especially 2D NMR techniques.
关键词：gnetuhainin P Gnetum hainanense gnetaceae ISORHAPONTIGENIN DIMER 
Studies on the Preparation of Bioactive Oligomerstilbene by Oxidative Coupling Reaction(Ⅰ)-Preparation of Shegansu B using Silver Oxide as Oxidant
《Chinese Chemical Letters》2000年第6期515-516,共2页Li Xin ZHOU Mao LIN(Institute of Materia Medica，Chinese Academy of Medical Sciences，Peking Union Medical College, Beijing 100050) 
篢he oxidative coupling reaction of isorhapontigenin using sliver oxide as oxidant afforded a major product, named shegansu B（2）， which was isolated from the roots of Belamcanda chinensis (L．)DC. Both the natural ...
关键词：ISORHAPONTIGENIN oligomerstilbene shegansu B oxidative coupling reaction silver oxide 
An Improved Synthesis of the Natural Product Isorhapontigenin被引量：1
《Chinese Chemical Letters》2000年第3期217-218,共2页Lian QIAN Zhi Song PIAO Lin WANG Zhi Zhong ZHAO 
Prot'essor M. I.in. \'ho kindly pro\ ided the natural product.
We have developed an alternative route to synthesize the natural product. isorhapotogenin. The synthetic product was characterized by IR and H-1-NMR in comparison with the corresponding natural product.
关键词：total synthesis ISORHAPONTIGENIN 
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