Electrochemical behavior of paclitaxel and its determination at glassy carbon electrode  

作　　者：Jayant I.Gowda Sharanappa T.Nandibewoor 

机构地区：[1]P.G.Department of Studies in Chemistry,Karnatak University,Dharwad 580003,Indi

出　　处：《Asian Journal of Pharmaceutical Sciences》2014年第1期42-49,共8页亚洲药物制剂科学（英文）

基　　金：One of the author(J.I.Gowda)thanks UGC,New Delhi,for the award of Research Fellowship in Science for Meritorious Stu-dents(RFSMS).

摘　　要：The electrochemical behavior of paclitaxel drug was studied at a glassy carbon electrode in phosphate buffer solutions using cyclic and differential-pulse voltammetric techniques.The oxidation process was shown to be irreversible over the pH range(3.0e10.4)and was diffusion controlled.Effects of anodic peak potential(E_(p)),anodic peak current(Ipa),scan rate,pH,heterogeneous rate constant(k^(0)),etc have been discussed.A possible electrooxidation mechanism was proposed.An analytical method was developed for the determination of paclitaxel in phosphate buffer solution at pH¼7.0 as a supporting electrolyte.The anodic peak current varied linearly with paclitaxel concentration in the range 1.0×10^-(6)M to 1.0×10^-(5)M with a limit of detection(LOD)of 1.23×10^(-8)M and limit of quantification(LOQ)of 4.10×10^(-8)M.The proposed method was successfully applied to the determination of paclitaxel in pure and real samples.

关 键 词：PACLITAXEL Glassy carbon electrode VOLTAMMETRY Injection analysis URINE 

分 类 号：TG1[金属学及工艺—金属学]