轻度认知障碍逆转为认知正常的研究进展  

Research Progress on Reversion of Mild Cognitive Impairment to Normal Cognition

作　　者：秦瑶 张嘉嘉 吴妍 葛晓燕 韩红娟 崔靖 白文琳 余红梅 QIN Yao;ZHANG Jiajia;WU Yan;GE Xiaoyan;HAN Hongjuan;CUI Jing;BAI Wenlin;YU Hongmei(Department of Health Statistics,Public Health of School,Shanxi Medical University,Taiyuan 030001,China;Department of Health Statistics,Public Health of School,Jinzhou Medical University,Jinzhou 121000,China;Department of Child and Adolescent Health,Public Health of School,Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学公共卫生学院卫生统计学教研室,山西省太原市030001 [2]锦州医科大学公共卫生学院卫生统计学教研室,辽宁省锦州市121000 [3]山西医科大学公共卫生学院儿少卫生学教研室,山西省太原市030001

出　　处：《中国全科医学》2021年第27期3506-3509,共4页Chinese General Practice

基　　金：国家自然科学基金面上项目(81973154);山西省科学技术厅面上青年基金项目(201901D211330);山西省教育厅优秀研究生创新项目(2019BY079)。

摘　　要：轻度认知障碍(MCI)通常被认为是阿尔茨海默病(AD)的高风险人群和治疗靶点。尽管每年有近10%~15%的MCI患者进展为AD,但MCI的认知轨迹高度可变,多数MCI患者并没有随着时间的推移而进展为AD,部分逆转为认知正常(NC)。迄今为止,关于MCI逆转为NC的意义尚无定论,且国内外MCI逆转为NC的系统研究仍然有限。本文系统梳理了MCI的逆转率、逆转原因、逆转的潜在影响因素及逆转的研究意义,提出了此类研究亟待解决的问题及展望。Mild cognitive impairment(MCI)is generally deemed to be a high-risk population and therapeutic target for Alzheimer's disease(AD).Although older adults with MCI have a 10%-15%annual risk of converting to probable AD,most MCIs remain stable,and partially reverse to normal cognition(NC).So far,the significance of the reversion of MCI to NC remains extremely inconclusive and controversial,and systematic research at home and abroad is still limited.This article systematically sorts out the reversal rate of MCI,various reasons and influential factors,and proposes the significance of the reversion of MCI to NC and the problems to be solved.

关 键 词：轻度认知障碍 阿尔茨海默病 逆转 认知正常 综述 

分 类 号：R741[医药卫生—神经病学与精神病学]