短肠综合征的治疗及进展  

Treatment Advances in Short Bowel Syndrome

作　　者：贾凌威[1] 王桂华 冯永东[1] Jia Lingwei;Wang Guihua;Feng Yongdong(Department of Gastrointestinal Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院胃肠外科中心,武汉430030

出　　处：《华中科技大学学报（医学版）》2021年第4期522-527,共6页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金资助项目(No.81922053)。

摘　　要：短肠综合征严重影响患者生存质量,妨碍正常社交,但病例少见,临床认识普遍不足。补充必须营养成分及促进肠道再适应、营养支持治疗、肠康复治疗以及各种形式的非移植手术是短肠综合征的有效治疗手段,近年来发展迅速。小肠移植是短肠综合征的挽救性治疗,但手术时间跨度大,移植后急性排斥仍是阻碍其发展的主要原因。该文就短肠综合征的病理生理机制和治疗进展展开综述,为临床医生根据患者病情开展个体化治疗提供理论依据。Short bowel syndrome(SBS)is a rare malabsorptive disorder which requires more clinical recognition and heavily impacts the quality of life and daily socializing of the patients.The management of patients with short bowel syndrome has been remarkably improved with the advances in home-based parenteral nutrition as well as enteral nutrition,together with increasing experience and the encouraging results with new drugs,such as teduglutide,which adds a new dimension to the management of SBS.The improved types of surgery including STEP and intestinal transplantation,are developed;however,the latter faces a huge obstacle concerning acute rejection.This review attempts to provide new understanding and recent approaches to a more individualized SBS therapy.

关 键 词：短肠综合征 营养支持 肠康复治疗 手术 

分 类 号：R574[医药卫生—消化系统]