局限期小细胞肺癌加速超分割放疗中使用不同分割剂量的效果及安全性研究  

Study on the effect and safety of using different fractional dose in accelerated hyperfractionated radiotherapy for localized small cell lung cancer

作　　者：李卓华[1] 沈纲[1] 林育超[2] LI Zhuo-hua;SHEN Gang;LIN Yu-chao(Ward Three of Radiotherapy,Guangdong Agricultural Reclamation Center Hospital,Guangdong Province,Zhanjiang524002,China;Department of Thoracic Surgery,Guangdong Agricultural Reclamation Center Hospital,Guangdong Province,Zhanjiang524002,China)

机构地区：[1]广东省农垦中心医院放疗三区,广东湛江524002 [2]广东省农垦中心医院胸外科,广东湛江524002

出　　处：《中国当代医药》2021年第21期97-99,103,共4页China Modern Medicine

基　　金：广东省湛江市科技计划项目(2017B01128)。

摘　　要：目的观察局限期小细胞肺癌在加速超分割放疗中使用不同分割剂量的效果及安全性。方法回顾性收集2018年1月—2019年12月广东省农垦中心医院胸外科收治的30例局限期小细胞肺癌患者进行研究,所有患者均行常规化疗联合加速超分割放疗,按照分割剂量分为两组,对照组(15例)总剂量为45 Gy,观察组(15例)总剂量为60 Gy。观察并比较两组的疗效、不良反应发生情况及生活质量。结果观察组的治疗有效率(80.00%)高于对照组(60.00%),差异有统计学意义(P<0.05)。两组在治疗期间的不良反应发生率比较,差异无统计学意义(P>0.05)。随访1个月,观察组的生活质量总评分[(80.22±3.46)分]高于对照组[(60.81±3.67)分],差异有统计学意义(P<0.05)。结论局限期小细胞肺癌加速超分割放疗,适当增加分割剂量,不良反应无明显增多,具有较高的安全性,且疗效更加显著,可有效提高患者的生活质量。Objective To observe the effect and safety of using different fractional dose in accelerated hyperfractionated radiotherapy for localized small cell lung cancer.Methods A retrospective collection of 30 patients with localized small cell lung cancer admitted to the Department of Thoracic Surgery,Guangdong Agricultural Reclamation Center Hospital from January 2018 to December 2019 was conducted for research.All patients received conventional chemotherapy combined with accelerated hyperfractionated radiotherapy,and they were divided into two groups according to the fractional dose.The total dose of the control group(15 cases)was 45 Gy,and the total dose of the observation group(15 cases)was 60 Gy.The efficacy,incidence of adverse reactions,and quality of life of the two groups were observed and compared.Results The effective rate of treatment in the observation group(80.00%)was higher than that in the control group(60.00%),and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups during the treatment period(P>0.05).At one month of follow-up,the total quality of life score in the observation group([80.22±3.46]points)was higher than that in the control group([60.81±3.67]points),the difference was statistically significant(P<0.05).Conclusion Localized small cell lung cancer by accelerated hyperfractionated radiotherapy,appropriately increasing the fractional dose has no significant increase in adverse reactions.It has higher safety and more significant curative effect,which can effectively improve the quality of life of patients.

关 键 词：小细胞肺癌 常规化疗 加速超分割放疗 安全性 

分 类 号：R735[医药卫生—肿瘤]