Advances in Mycobacterium siderophore-based drug discovery  

作　　者：Jun-li He Jian-ping Xien 

机构地区：[1]Institute of Modern Biopharmaceuticals,Southwest University,Chongqing 400715,China

出　　处：《Acta Pharmaceutica Sinica B》2011年第1期8-13,共6页药学学报（英文版）

基　　金：supported by the National Key Infectious Disease Project(No.2008ZX10003-006);National Natural Science Foundation(Grant No.81071316);Excellent PhD Thesis Fellowship of Southwest University(Nos.kb2009010 and ky2009009);the Fundamental Research Fund for the Central Universities(No.XDJK2009A003);Natural Science Foundation Project of CQ CSTC(No.2010BB5002)。

摘　　要：Tuberculosis remains a public health threat of global proportions.Iron is a scarce resource indispensable to both host and pathogen during infection with Mycobacterium tuberculosis,the causative agent of tuberculosis.Siderophores are critical molecules for iron acquisition under iron-limiting conditions and,as a very efficient pathogen,M.tuberculosis has evolved elaborate siderophores knowledge of which is being intensively translated into clinical practice.This paper summarizes the structures,types and physiological functions of Mycobacterium siderophores with emphasis on siderophore-inspired design of drugs and drug delivery vehicles.

关 键 词：TUBERCULOSIS Mycobacterium tuberculosis SIDEROPHORE Drug vector Drug design 

分 类 号：Q93[生物学—微生物学]