FS⁃SBK术、SMILE术、LASIK术对近视及近视散光患者角膜生物力学、中央角膜内皮细胞的影响  

Effects of FS⁃SBK,SMILE and LASIK on corneal biomechanics and central corneal endothelial cells in myopia and myopic astigmatism

作　　者：张醇[1] 黎明[1] 应方微[1] 贾惠莉[1] 杨娟[1] 王时娟 ZHANG Chun;LI Ming;YING Fangwei;JIA Huili;YANG Juan;WANG Shijuan(Ophthalmology Department,Shenzhen Eye Hospital,Shenzhen 518040,China)

机构地区：[1]深圳市眼科医院,广东深圳518040

出　　处：《实用医学杂志》2021年第14期1837-1841,1845,共6页The Journal of Practical Medicine

基　　金：深圳市科技计划项目(编号:JCYJ20170306140020487)。

摘　　要：目的研究飞秒激光制瓣的SBK术(FS⁃SBK术)、小切口飞秒激光基质透镜取出术(SMILE术)、准分子激光原位角膜磨镶术(LASIK术)对近视及近视散光患者角膜生物力学、中央角膜内皮细胞的影响。方法选取2019年1-6月我院收治的近视散光患者150例,采用分层抽样法将患者分为FS⁃SBK术组、SMILE术组和LASIK术组各50例。FS⁃SBK术组使用FS⁃SBK术治疗,SMILE术组使用SMILE术治疗,LASIK术组使用LASIK术治疗,评价患者角膜生物力学指标、中央角膜内皮细胞指标ECD、CV、6A水平、角膜像差、视力、屈光度及并发症发生情况。结果SMILE术组患者角膜生物力学指标、中央角膜内皮细胞指标ECD、CV、6A水平、角膜像差、屈光度、并发症发生率低于FS⁃SBK术组和LASIK术组,视力高于FS⁃SBK术组和LASIK术组,差异有统计学意义(P<0.05)。FS⁃SBK术组和LASIK术组角膜生物力学指标、中央角膜内皮细胞指标ECD、CV、6A水平、角膜像差、视力、屈光度和并发症发生率比较,差异无统计学意义(P>0.05)。结论与FS⁃SBK术和LASIK术相比,SMILE术可显著改善角膜生物力学指标、中央角膜内皮细胞指标ECD、CV、6A水平、角膜像差、屈光度、并发症发生率,促进患者视力恢复。Objective To study the effects of femtosecond laser flap making SBK(FS⁃SBK),small incision femtosecond laser stromal lens extraction(SMILE),excimer laser in situ keratomileusis(LASIK)on corneal biomechanics and central corneal endothelial cells in myopic and astigmatic patients.Methods From January 2019 to June 2019,150 cases of myopic astigmatism were selected and divided into FS⁃SBK group,SMILE group and LASIK group through stratified sampling method.FS⁃SBK group was treated with FS⁃SBK,SMILE group was treated with SMILE,LASIK group was treated with LASIK.The corneal biomechanical index,central corneal endothelial cell index(ECD,CV,6a),corneal aberration,vision and diopterand complications were evaluated.Results These indicators were lower in SMILE group than in FS⁃SBK group and LASIK group,including corneal biomechanical index,central corneal endothelial cell index levels(ECD,CV,6a),corneal aberration,diopter andcomplication rate.But the visual acuity was higher in SMILE group than in FS⁃SBK group and LASIK group(P<0.05).There were no significant differences between FS⁃SBK group and LASIK group in corneal biomechanical index,central corneal endothelial cell index levels(ECD,CV,6a),corneal aberration,vision,diopter and complication rate(P>0.05).Conclusion Compared with FS⁃SBK and LASIK,SMILE can significantly improve the corneal biomechanical index,central corneal endothelial cell index levels(ECD,CV,6a),corneal aberration,diopter,complication rate,and promote visual recovery.

关 键 词：飞秒激光制瓣的SBK术 小切口飞秒激光基质透镜取出术 准分子激光原位角膜磨镶术 近视 近视散光 

分 类 号：R778.11[医药卫生—眼科]