Implications of helminth immunomodulation on COVID-19 co-infections  

作　　者：Nathalie Chacon Leonor Chacin-Bonilla Italo M.Cesari 

机构地区：[1]School of Medicine.Department of Public Health.University of Texas Rio Grande Valley,Edinburg,USA [2]Institute of Clinical Research.Zulia State University,Maracaibo,Venezuela [3]Immunoparasitology Laboratory,Center for Microbiology and Cell Biology,Venezuelan Institute of Scientific Research,Altos de Pipe,Venezuela

出　　处：《Life Research》2021年第3期81-96,共16页TMR生命研究

摘　　要：Coronavirus disease 2019(COVID-19)and helminths infections can be in a synergistic epidemic in developing and suburban areas of industrialized countries.The coinfected hosts will derive a parasite-specific Th2 innate and adaptive immune response with CD4+T cells,eosinophils,interleukin-4,interleukin-5,and interleukin-10.In the early stages of severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)infection,virus-specific Th1 cytotoxic CD8+T cell,interleukin-6,interferon-γ,and interleukin-27 by lung are keys in controlling viral replication in the lung epithelial cells and limiting the pathology to other organs,like the intestine.CD4+and CD8+T cells are associated with protective immunity against and during COVID-19.However,viral evasion mechanisms occur.Interference of the interferon-γsecretion,like in helminths immunomodulation,can contribute to COVID-19 severity.Immunomodulation can result in mild,moderate,or severe COVID-19 depending on which helminth is coinfecting by regulating or avoiding host cytokine and pro-inflammatory response,decreasing viral load,and affecting vaccine-induced antibody response.We discuss the implications of immunomodulation on COVID-19 caused by helminth co-infection and for public health in the context of COVID-19 vaccine use in helminth endemic zones.

关 键 词：CO-INFECTION COVID-19 Developing country HELMINTH IMMUNOMODULATION SARS-CoV-2 

分 类 号：R51[医药卫生—内科学]