Entry,egress and vertical transmission of SARS-CoV-2  

作　　者：Hui Zhang Hong Zhang 

机构地区：[1]National Laboratory of Biomacromolecules,CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China [2]College of Life Sciences,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Journal of Molecular Cell Biology》2021年第3期168-174,共7页分子细胞生物学报（英文版）

基　　金：supported by grants to H.Z.from the National Natural Science Foundation of China(31421002,31561143001,31630048,and 31790403);Chinese Ministry of Science and Technology(2017YFA0503401);Beijing Municipal Science and Technology Committee(Z181100001318003);Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB19000000);Key Research Program of Frontier Sciences,CAS(QYZDY-SSW-SMC006).

摘　　要：The high infectivity and pathogenicity of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have caused the COVID-19 outbreak,one of the most devastating pandemics in more than a century.This pandemic has already left a trail of destruction,including enormous loss of life,a global economic slump,and widespread psychological damage.Despite assiduous world-wide endeavors,an effective cure for COVID-19 is still lacking.Surprisingly,infected neonates and children have relatively mild clinical manifestations and a much lower fatality rate than elderly adults.Recent studies have unambiguously demonstrated the vertical transmission of SARS-CoV-2 from infected pregnant women to fetuses,which creates yet another challenge for disease prevention.In this review,we will summarize the molecular mechanism for entry of SARS-CoV-2 into host cells,the basis for the failure of the lungs and other organs in severe acute cases,and the evidence for congenital transmission.

关 键 词：SARS-CoV-2 COVID-19 ACE2 TMPRSS2 placental transmission 

分 类 号：R563.1[医药卫生—呼吸系统]