周细胞介导脑微循环障碍在中枢神经系统疾病中的相关性研究  

Correlation of pericyte-mediated cerebral microcirculation disturbance with central nervous system diseases

作　　者：郑少锐 陈祥荣[2] 王守森 Zheng Shaorui;Chen Xiangrong;Wang Shousen(Department of Neurosurgery,Fuzong Clinical Medical college,Fujian Medical University,Fuzhou 350025,China;Department of Neurosurgery,Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China;Hospital of Joint Logistic Support Force of People's Liberation Army,Fuzhou 350025,China)

机构地区：[1]福建医科大学福总临床医学院神经外科,福州350025 [2]福建医科大学附属第二医院神经外科,泉州362000 [3]解放军联勤保障部队第九〇〇医院神经外科,福州350025

出　　处：《中华神经医学杂志》2021年第7期738-742,共5页Chinese Journal of Neuromedicine

基　　金：全军后勤科技重大项目(AHJ14J001)。

摘　　要：周细胞是微血管的一种壁细胞,与神经元、星形胶质细胞、小胶质细胞、血管内皮细胞、血管平滑肌细胞共同构成神经血管单元,维持脑基本功能。周细胞功能障碍会导致脑微循环功能障碍,与多种神经系统疾病的发生发展有关。本文结合近年来的相关文献,围绕周细胞的特性、鉴别、亚型、与脑微循环的关系以及与中枢神经系统疾病的相关性进行综述。Pericytes are a kind of microvascular parietal cells,which constitute neurovascular units together with neurons,astrocytes,microglia,vascular endothelial cells and vascular smooth muscle cells to maintain the basic function of the brain.Pericyte dysfunction can lead to cerebral microcirculation dysfunction,which is related to the occurrence and development of a variety of nervous system diseases.This article reviews the characteristics,identification and subtypes of pericytes,their relations with cerebral microcirculation,and their correlation with central nervous system diseases.

关 键 词：周细胞 脑微循环 神经血管耦连 中枢神经系统疾病 

分 类 号：R741.02[医药卫生—神经病学与精神病学]