Antibiotic drugs targeting bacterial RNAs  

作　　者：Weiling Hong Jie Zeng Jianping Xie 

机构地区：[1]Institute of Modern Biopharmaceuticals,State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area,Key Laboratory of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region,School of Life Sciences,Southwest University,Chongqing 400715,China

出　　处：《Acta Pharmaceutica Sinica B》2014年第4期258-265,共8页药学学报（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.81371851,81071316,81271882 and 81301394);the New Century Excellent Talents in Universities(No.NCET-11-0703);the National Megaprojects for Key Infec-tious Diseases(No.2008ZX10003-006);an excellent Ph.D Thesis Fellowship of Southwestern University(Nos.kb2010017 and ky2011003);the Fundamental Research Fund for Central Universities(Nos.XDJK2011D006,XDJK2012D011,XDJK2012D007,XDJK2013D003 and XDJK2014D040);the Natural Science Founda-tion Project of CQ CSTC(No.CSTC 2010BB5002);the Chongqing Municipal Committee of Education for Postgraduate Excellence Program(No.YJG123104);an Undergraduate Teaching Reform Program(No.2013JY201).

摘　　要：RNAs have diverse structures that include bulges and internal loops able to form tertiary contacts or serve as ligand binding sites.The recent increase in structural and functional information related to RNAs has put them in the limelight as a drug target for small molecule therapy.In addition,the recognition of the marked difference between prokaryotic and eukaryotic rRNA has led to the development of antibiotics that specifically target bacterial rRNA,reduce protein translation and thereby inhibit bacterial growth.To facilitate the development of new antibiotics targeting RNA,we here review the literature concerning such antibiotics,mRNA,riboswitch and tRNA and the key methodologies used for their screening.

关 键 词：RNA ANTIBIOTICS Drug targeting BACTERIA 

分 类 号：R73[医药卫生—肿瘤]