Divergent Synthesis of N-Heterocycles by Merging Borane- Mediated Cyclopropane Ring-Opening and Hydride Abstraction  

作　　者：Zi-Yu Zhang Jie Ren Ming Zhang Xiu-Fang Xu Xiao-Chen Wang 

机构地区：[1]State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China

出　　处：《Chinese Journal of Chemistry》2021年第6期1641-1645,共5页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21871147 and 91956106);the Natural Science Foundation of Tianjin(Nos.20JCZDJC00720 and 20JGQJC00030);the NCC Fund(No.NCC2020PY10);the Fundamental Research Funds for Central Universities(No.2122018165).X.-C.W.thanks the Tencent Foundation for support via the Xplorer Prize.This paper is dedicated to the 100th anniversary of the chemistry department at Nankai University.

摘　　要：Herein,we report the synthesis of N-heterocycles by borane-catalyzed dehydrogenative cyclization of 2-cyclopropyl-N,N-dimethyl-anilines.Borane-mediated cyclopropane ring-opening and borane-mediated hydride abstraction from an N-methyl group are the key steps.The substituent at the cyclopropyl unit was found to greatly influence the reaction pathway and thus determined the major reaction product.

关 键 词：BORANES Lewis acids Cyclization HETEROCYCLES Hydrides 

分 类 号：O62[理学—有机化学]