Guajamers A-I, Rearranged Polycyclic Phloroglucinol Meroterpenoids from Psidium guajava Leaves and Their Antibacterial Activity  

作　　者：Ji-Wu Huang Chuang-Jun Li Jing-Zhi Yang Chuan Li Yu Zhang Ke Liu Yue Yu Jian-Dong Jiang Dong-Ming Zhang 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

出　　处：《Chinese Journal of Chemistry》2021年第5期1129-1137,共9页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(No.21772234);the National New Drug Innovation Major Project of China(Nos.2018ZX09735006,2018ZX09711001-001,and 2018ZX09711001-002-010);the independent project of State Key Laboratory of Bioactive Substance and Function of Natural Medicines(No.GTZA201803).

摘　　要：Eight new polycyclic phloroglucinol meroterpenoids guajamers A-H(1-8),a methylated benzoylphloroglucinol meroterpenoid guajamer I(9)representing a new skeleton,and two known analogues(10 and 11)were isolated from the leaves of Psidium guajava.The structures of new molecules were elucidated by detailed analysis of spectroscopic data,and those of 1,2,8,and 9 were unambiguously confirmed by single-crystal X-ray diffraction study.Structurally,compounds 1-8 were sesquiterpene and monoterpene-based meroterpenoids with rearranged skeletons,while compound 9 was the first case of 3-alkyl-5-formyl-benzoylphloroglucinol-coupled sesquiterpene containing an unusual C-l-spiro-fused 6/6/9/4 polycyclic skeleton.In addition,all the isolated compounds were evaluated for their antibacterial activity against three bacterial strains,and most of them(compounds 2-7,10,and 11)showed antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis with MIC values of 8-32 μmol/L.These findings suggested that meroterpenoids isolated from Psidium guajava can be considered as potential antibacterial leading compounds for pharmaceutical industry.

关 键 词：Psidium guajava MEROTERPENOIDS X-ray crystal structure Structural elucidation Antibacterial activity 

分 类 号：O62[理学—有机化学]