单胺氧化酶A在前列腺癌中的研究现状  

Current state of monoamine oxidase A in prostate cancer

作　　者：谭伟[1] 袁野 胡自力[1] Tan Wei;Yuan Ye;Hu Zili(Department of Urology Surgery,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院泌尿外科,400010

出　　处：《国际外科学杂志》2021年第6期416-420,共5页International Journal of Surgery

摘　　要：近年来,前列腺癌的发病率日渐升高,对于新的、有效的前列腺癌的诊治方法的需求也随之日益迫切。单胺氧化酶A(MAO-A)是一种线粒体结合酶,在一些神经递质的脱氨降解中发挥重要作用,既往多用于神经及精神类疾病的治疗。近年来,越来越多的研究表明,MAO-A在前列腺癌的发生、发展、转移等过程中起重要作用。目前,MAO-A已成为前列腺癌一种潜在的治疗靶点而被广泛关注。在此,本文就MAO-A在前列腺癌的发生、发展、转移等过程中可能的机制及MAO-A在前列腺癌的诊治中的应用作一综述。Recent years,the incidence of prostate cancer is increasing,and the need of novel and effective diagnosis and treatment for prostate cancer is becoming more and more urgent.Monoamine oxidase A(MAO-A)is a mitochondrial binding enzyme,which plays an important role in the deamination of some neurotransmitters.Currentlly,some novel studies have shown that MAO-A plays an important role in the occurrence,development and metastasis of prostate cancer.At present,MAO-A has become a potential therapeutic target of prostate cancer and has been widely concerned.This article make a review on the possible mechanism of MAO-A in the occurrence,development and metastasis of prostate cancer and the application of MAO-A in the diagnosis and treatment of prostate cancer.

关 键 词：前列腺肿瘤 单胺氧化酶A 肿瘤转移 

分 类 号：R737.25[医药卫生—肿瘤]