单相抑郁与双相抑郁患者T淋巴细胞亚群特征  

Characteristics of T lymphocyte subsets in patients with unipolar depression and bipolar depression

作　　者：杨胜良[1] 黄龙武[2] 戴红[1] 钱敏才[1] 洪秀娟 沈仲夏[1] YANG Shengliang;HUANG Longwu;DAI Hong;QIAN Mincai;HONG Xiujuan;SHEN Zhongxia(Department of Psychosomatics,Huzhou Third People′s Hospital in Zhejiang Province,Huzhou 313000,China;De-partment of Pathology,Huzhou Third People′s Hospital in Zhejiang Province,Huzhou 313000,China;Key Labora-tory of Psychiatry,Huzhou Third People′s Hospital in Zhejiang Province,Huzhou 313000,China)

机构地区：[1]浙江省湖州市第三人民医院心身科,浙江湖州313000 [2]浙江省湖州市第三人民医院病理科,浙江湖州313000 [3]浙江省湖州市第三人民医院精神医学重点实验室,浙江湖州313000

出　　处：《中国现代医生》2021年第18期23-26,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2020KY942);浙江省医药卫生科技计划项目(2018KY785)。

摘　　要：目的比较单相抑郁、双相抑郁患者的外周血T淋巴细胞亚群特征,寻找单双相抑郁的免疫学鉴别诊断指标。方法采用前瞻性研究方法,收集2018年6月至2019年10月我院心身科住院患者,其中单相抑郁组600例、双相抑郁组60例,本院体检健康对照组30例。留取三组血样标本,采用CD系列细胞检测玻片检测外周血中CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)细胞亚群计数,并进行相关分析。结果单相抑郁组、双相抑郁组与健康对照组三组间外周血CD3^(+)、CD4^(+)、CD8^(+)比较,差异均有统计学意义(P<0.001)。其中单相抑郁组CD3^(+)、CD4^(+)、CD8^(+)计数低于双相抑郁组和健康对照组,差异均有统计学意义(P<0.01);双相抑郁组CD3^(+)、CD8^(+)计数均低于健康对照组,差异均有统计学意义(P<0.01);双相抑郁组CD4^(+)计数低于健康对照组,但差异无统计学意义(P>0.05)。结论单相抑郁、双相抑郁患者均存在T淋巴细胞亚群分布异常,T淋巴细胞亚群可以尝试用于鉴别单、双相抑郁。Objective To compare the characteristics of peripheral blood T lymphocyte subsets in patients with unipolar depression and bipolar depression,to find immunological differential diagnosis indicators for unipolar and bipolar de-pression.Methods A prospective research method was used to select patients hospitalized in the Department of Psycho-somatics in our hospital from June 2018 to October 2019.There were 600 patients in the unipolar depression group and 60 patients in the bipolar depression group.A total of 30 healthy people in the hospital were selected as the healthy control group.Blood samples were collected from the three groups.The counts of CD3^(+),CD4^(+),CD8^(+) and CD4^(+)/CD8^(+)cell substes in peripheral blood were detected using CD series cell detection slides,and related analysis was performed.Results There were statistically significant differences in the counts of CD3^(+),CD4^(+)and CD8^(+)in peripheral blood among the unipolar depression group,the bipolar depression group and the healthy control group(P<0.001).The counts of CD3^(+),CD4^(+)and CD8^(+)in the unipolar depression group were lower than those in the bipolar depression group and the healthy control group,with statistically significant differences(P<0.01).The counts of CD3^(+) and CD8^(+)in the bipolar depression group were lower than those in the healthy control group,with statistically significant differences(P<0.01).The counts of CD4+in the bipolar depression group were lower than those in the healthy control group,but without statistically significant differences(P>0.05).Conclusion Patients with unipolar depression and bipolar depression have abnormal distribution of T lymphocyte subsets.T lymphocyte subsets can be used to differentiate between unipolar depression and bipolar depression.

关 键 词：单相抑郁 双相抑郁 CD4^(+) CD8^(+) 

分 类 号：R749.42[医药卫生—神经病学与精神病学]