从水通道蛋白诠释“肾主水”的现代科学内涵  

Interpretation of Modern Scientific Connotation of“Kidney Governing Water”from Aquaporins

作　　者：刘娇[1,2] 陈明 陈鑫 陈梅[1,2] LIU Jiao;CHEN Ming;CHEN Xin;CHEN Mei(Chengdu University of Chinese Medicine,Chengdu 610075,China;The Affiliated Hospital of Chengdu University of Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学,四川成都610075 [2]成都中医药大学附属医院,四川成都610075

出　　处：《山东中医杂志》2021年第8期884-889,共6页Shandong Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:81973673)。

摘　　要：“肾主水”理论作为中医藏象理论的主要内容之一,最早见于《黄帝内经》,强调“肾”在调节机体水液运行及代谢方面起主宰作用。水通道蛋白是一族细胞膜上转运水分子的特异性孔道蛋白。研究证实水通道蛋白在肾脏组织中广泛表达,且与机体水液代谢密切相关。通过对“肾主水”及水通道蛋白相关文献的复习与研究,提出水通道蛋白在“肾主水”功能中发挥重要作用,可诠释“肾主水”的现代医学内涵,为中医药治疗肾性水液代谢紊乱相关性疾病提供新思路。参考文献67篇。The“kidney governing water”theory,one major part of the theory of visceral manifestation in traditional Chinese medicine(TCM),was first seen in the The Yellow Emperor’s Inner Classic.This theory emphasizes that the kidney plays a dominant role in regulating the transportation and metabolism of body fluids.Aquaporins are a family of specific channel proteins that transport water molecules on the cell membrane.Studies have verified that aquaporins are widely expressed in kidney tissues and are closely related to the metabolism of body fluids in the body.Through reviewing the literature on“kidney governing water”and aquaporins,it is proposed that aquaporins play an important role in the function of“kidney governing water”,which can explain the modern medical connotation of the theory,and can provide new ideas for the TCM treatment of nephrotic disorder of body fluids metabolism.There are 67 research papers cited.

关 键 词：肾主水 水通道蛋白 水液代谢 中医理论 研究进展 

分 类 号：R223.1[医药卫生—中医基础理论]