Alginate encapsulated mesoporous silica nanospheres as a sustained drug delivery system for the poorly water-soluble drug indomethacin  

作　　者：Liang Hu Changshan Sun Aihua Song Di Chang Xin Zheng Yikun Gao Tongying Jiang Siling Wang 

机构地区：[1]Department of Pharmaceutics,Shenyang Pharmaceutical University,P.O.Box 32,Liaoning Province,Shenyang 110016,China [2]Testing Center in School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China [3]School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2014年第4期183-190,共8页亚洲药物制剂科学（英文）

基　　金：This work was supported by National Basic Research Program of China(973 Program)(2009CB930300);National Natural Science Foundation of China(81072605);Shenyang Special Fund for Exploration of Intellectual Resources.

摘　　要：We applied a combination of inorganic mesoporous silica material,frequently used as drug carriers,and a natural organic polymer alginate(ALG),to establish a sustained drug delivery system for the poorly water-soluble drug Indomethacin(IND).Mesoporous silica nanospheres(MSNs)were synthesized using an organic template method and then functionalized with aminopropyl groups through postsynthesis.After drug loading into the pores of aninopropyl functionalized MSNs(AP-MSNs),IND loaded AP-MSNs(IND-AP-MSNs)were encapsulated by ALG through the ionic interaction.The effects of surface chemical groups and ALG layer on IND release were systematically studied using scanning electron microscopy(SEM),transmission electron microscopy(TEM),nitrogen adsorption,zetapotential analysis and TGA analysis.The surface structure and surface charge changes of the ALG encapsulated AP-MSNs(ALG-AP-MSNs)were also investigated.The results showed that sustained release of IND from the designed drug delivery system was mainly due to the blockage effect from the coated ALG.We believe that this combination will help designing oral sustained drug delivery systems for poorly water-soluble drugs.

关 键 词：INDOMETHACIN Mesoporous silica nanospheres Aminepropyl group ALGINATE Sustained release Poorly water-soluble drug 

分 类 号：TB3[一般工业技术—材料科学与工程]