卵巢浆液性上皮癌患者术前NLR与临床特征及预后的相关性  

Correlation between preoperative NLR and clinical features,prognosis in patients with ovarian serous epithelioma

作　　者：李文娟[1] 白枫[1] 赵琳[1] 肖莹 马贺迪 LI Wen-juan;BAI Feng;ZHAO Lin(Department of Gynecology,Liaoning Provincial People's Hospital,Shenyang Liaoning 110016,China)

机构地区：[1]辽宁省人民医院妇科,辽宁沈阳110016

出　　处：《临床和实验医学杂志》2021年第13期1430-1433,共4页Journal of Clinical and Experimental Medicine

基　　金：辽宁省自然科学基金指导计划项目(编号:20180550314)。

摘　　要：目的探讨卵巢浆液性上皮癌患者术前中性粒细胞/淋巴细胞比值(NLR)与临床特征及预后的相关性。方法回顾性分析2011年1月至2015年12月辽宁省人民医院卵巢浆液性上皮癌患者133例,分为高NLR组(NLR≥3)80例和低NLR组(NLR<3)53例。收集患者临床特征资料、无进展生存期(PFS)、总生存期(OS),进行生存曲线分析和COX回归模型分析。结果术前NLR与年龄、是否远处转移、是否绝经、有无生殖系统恶性肿瘤家族史无关联(P>0.05);术前NLR与FIGO分期、分化程度、术前CA125水平、腹水有关联(P<0.05)。高NLR组的中位PFS为41.5个月,中位OS为53.0个月;低NLR组的中位PFS为59.3个月,中位OS为74.0个月,差异有统计学意义(P<0.05)。高NLR组3、5年无进展生存率为52.20%、31.25%,低NLR组为71.70%、49.06%,差异有统计学意义(P<0.05)。FIGO分期Ⅲ~Ⅳ期(HR=3.050)、远处转移(HR=2.354)、术前NLR≥3(HR=2.188)是影响卵巢浆液性上皮癌患者预后的独立危险因素。结论术前NLR与卵巢浆液性上皮癌FIGO分期、分化程度、肿瘤标志物等临床特征密切相关,对评估患者预后有较高价值。Objective To explore the correlation between preoperative neutrophil/lymphocyte ratio(NLR)and clinical features,prognosis in patients with ovarian serous epithelioma.Methods A total of 133 patients with ovarian serous epithelioma admitted to Liaoning Provincial People's Hospital from January 2011 to December 2015 were retrospectively analyzed.They were divided into high NLR group(NLR not lower than 3,80 cases)and low NLR group(NLR lower than 3,53 cases).The data such as clinical features,progression free survival(PFS)and overall survival(OS)were collected to conduct survival curve analysis and COX regression model analysis.Results The preoperative NLR was not related with age,distant metastasis,menopause or family history of reproductive system malignancies(P>0.05),while related with FIGO staging,differentiation degree,preoperative CA125 level and ascites(P<0.05).Median PFS and OS in high NLR group and low NLR group were(41.5 months,53.0 months)and(59.3 months,74.0 months),the differences were statistically significant(P<0.05).The 3-year and 5-year PFS in high NLR group and low NLR group were(52.20%,31.25%)and(71.70%,49.06%),the differences were statistically significant(P<0.05).FIGO staging at stageⅢ-Ⅳ(HR=3.050),distant metastasis(HR=2.354)and preoperative NLR not lower than 3(HR=2.188)were independent risk factors affecting the prognosis of patients with ovarian serous epithelioma.Conclusion Preoperative NLR is closely related to FIGO staging,differentiation degree and tumor markers in patients with ovarian serous epithelioma,which are of high value in evaluating their prognosis.

关 键 词：卵巢浆液性上皮癌 中性粒细胞/淋巴细胞比值 无进展生存期 

分 类 号：R737.31[医药卫生—肿瘤]