激光联合牙周基础治疗对种植体周围炎患者龈沟液中TNF-α、b-FGF及IL-1β水平的影响  

Effects of laser combined with periodontal basic treatment on the levels of TNF-α,b-FGF and IL-1βin gingival crevicular fluid of peri-implantitis patients

作　　者：董方 李艳莉 童远武 DONG Fang;LI Yan-li;TONG Yuan-wu(Department of Stomatology,Sanya Central Hospital(Third People's Hospital of Hainan Province),Sanya Hainan 572000,China)

机构地区：[1]三亚中心医院(海南省第三人民医院)口腔科,海南三亚572000

出　　处：《临床和实验医学杂志》2021年第13期1447-1450,共4页Journal of Clinical and Experimental Medicine

基　　金：海南省卫生计生行业科研项目(编号:19A200134);三亚市医疗卫生科技创新项目(编号:2018YW05)。

摘　　要：目的研究激光联合牙周基础治疗对种植体周围炎患者龈沟液肿瘤坏死因子α(TNF-α)、碱性成纤维细胞生长因子(b-FGF)及白细胞介素1β(IL-1β)水平的影响。方法采用回顾性分析方法,研究对象为2019年1月至2020年1月三亚中心医院收治的82例种植体周围炎患者,根据治疗方式不同分为对照组41例与研究组41例。对照组选用牙周基础治疗,研究组选用激光联合牙周基础治疗。比较2组患者治疗前、治疗后12周龈沟出血指数、牙周探诊深度、临床附着丧失水平与龈沟液内细胞因子(IL-8、b-FGF及IL-1β)水平,并对比总有效率。结果治疗前,2组患者龈沟出血指数、牙周探诊深度、临床附着丧失水平与龈沟液内龈沟液内细胞因子水平比较,差异均无统计学意义(P>0.05);治疗后12周,研究组患者的龈沟出血指数、牙周探诊深度、临床附着丧失水平分别为0.53±0.21、(2.87±0.99)mm、(2.49±1.05)mm,明显低于对照组[1.01±0.58、(3.85±1.18)mm、(3.37±1.23)mm],差异均有统计学意义(P<0.05);研究组龈沟液内b-FGF水平为(20.16±1.59)μg/L,明显高于对照组[(16.58±1.38)μg/L],IL-8及IL-1β水平为(15.43±2.02)、(1.95±0.25)μg/L,明显低于对照组[(20.37±2.18)、(2.19±0.23)μg/L],差异均有统计学意义(P<0.05)。研究组患者治疗总有效率(97.56%)明显高于对照组(82.93%),差异有统计学意义(P<0.05)。结论种植体周围炎患者治疗中激光联合牙周基础治疗的效果显著,可有效改善龈沟液内细胞因子水平,减少龈沟出血指数、牙周探诊深度及临床附着丧失水平。Objective To study the effect of laser combined with basic periodontal treatment on the levels of tumor necrosis factor-α(TNF-α),basic fibroblast growth factor(b-FGF)and interleukin 1β(IL-1β)in gingival crevicular fluid of patients with peri-implantitis.Methods Retrospective analysis was performed on 82 patients with perimplantitis admitted to Sanya Central Hospital from January 2019 to January 2020,and they were divided into control group 41 cases and research group 41 cases according to different treatment methods.Periodontal basic treatment was used in the control group,and laser combined with periodontal basic treatment was used in the research group.Gingival crevicular fluid bleeding index,periodontal probing depth,clinical attachment loss and cytokines(IL-8,b-FGF and IL-1β)in gingival crevicular fluid were compared between the two groups before and after 12 weeks of treatment,and the total effective rate after treatment was compared.Results There were no significant difference in the gingival crevicular bleeding index,the depth of periodontal exploration,the level of clinical attachment loss and the cytokine level in the gingival crevicular fluid before treatment between the two groups of patients(P>0.05);after 12 weeks of treatment,the gingival sulcus bleeding index,periodontal probing depth,and clinical attachment loss level of the study group were 0.53±0.21,(2.87±0.99)mm,(2.49±1.05)mm,respectively,which were significantly lower than those in the control group[1.01±0.58,(3.85±1.18)mm,(3.37±1.23)mm],the differences were statistically significant(P<0.05);the b-FGF level of the gingival crevicular fluid in the study group was(20.16±1.59)μg/L,which was significantly higher than that in the control group[(16.58±1.38)μg/L],the levels of IL-8 and IL-1βwere(15.43±2.02),(1.95±0.25)μg/L,which were significantly lower than those in the control group[(20.37±2.18),(2.19±0.23)μg/L],the differences were statistically significant(P<0.05).The total effective rate of treatment in the study group(97.56

关 键 词：种植体周围炎 激光 牙周基础治疗 龈沟液 细胞因子 

分 类 号：R781.4[医药卫生—口腔医学]