Enhancement of solubility and therapeutic potential of poorly soluble lovastatin by SMEDDS formulation adsorbed on directly compressed spray dried magnesium aluminometasilicate liquid loadable tablets: A study in diet induced hyperlipidemic rabbits  

作　　者：Mohd Javed Qureshi Chitneni Mallikarjun Wong Gan Kian 

机构地区：[1]Department of Pharmaceutical Technology,School of Pharmacy,Taylors University,Lakeside Campus,Selangor,Malaysia [2]Department of Pharmaceutical Technology,School of Pharmacy,International Medical University,Kuala Lumpur,Malaysia

出　　处：《Asian Journal of Pharmaceutical Sciences》2015年第1期40-56,共17页亚洲药物制剂科学（英文）

基　　金：International Medical University(IMU),Malaysia for financially supporting the present work under the research grant number BPharm B0108_Res322011.

摘　　要：The aim of present study was to formulate and evaluate a self-microemulsifying drug delivery systems(SMEDDS)containing lovastatin and to further explore the ability of porous Neusilin■ US2 tablet as a solid carrier for SMEDDS.SMEDDS formulations of varying proportions of peceol,cremophor RH 40 and transcutol-P were selected and subjected to invitro evaluation,including dispersibility studies,droplet size,zeta potential measurement and release studies.The results indicated that the drug release profile of lovastatin from SMEDDS formulations was statistically significantly higher(p-value<0.05)than the plain lovastatin powder.Thermodynamic stability studies also confirmed the stability of the prepared SMEDDS formulations.The optimized formulation,which consists of 12% of peceol,44% of cremophor RH 40,and 44% of transcutol-P was loaded into directly compressed liquid loadable tablet of Neusilin■ US2 by simple adsorption method.In order to determine the ability of Neusilin®US2 as a suitable carrier pharmacodynamics study were also carried out in healthy diet induced hyperlipidemic rabbits.Animals were administered with both liquid SMEDDS and solid SMEDDS as well.From the results obtained,Neusilin■ was found to be a suitable carrier for SMEDDS and was equally effective in reducing the elevated lipid profile.In conclusion,liquid loadable tablet(LLT)is predicted to be a promising technique to deliver a liquid formulation in solid state.

关 键 词：LOVASTATIN Self-microemulsifying drug delivery system(SMEDDS) Neusilin■US2 Liquid loadable tablet Solid carrier system Pharmacodynamics studies 

分 类 号：R94[医药卫生—药剂学]