Montmorillonite/Poly(L-Lactide)microcomposite spheres as reservoirs of antidepressant drugs and their controlled release property  

作　　者：Shalini Rajkumar Bhavesh D.Kevadiya Hari C.Bajaj 

机构地区：[1]Institute of Science,Nirma University,Ahmedabad 382481,Gujarat,India [2]Discipline of Inorganic Materials and Catalysis,Central Salt and Marine Chemicals Research Institute,Council of Scientific and Industrial Research(CSIR),Gijubhai Badheka Marg,Bhavnagar 364021,Gujarat,India

出　　处：《Asian Journal of Pharmaceutical Sciences》2015年第5期452-458,共7页亚洲药物制剂科学（英文）

基　　金：Authors are thankful to Director,CSMCRI,Bhavnagar for pro-viding necessary infrastructure facilities and the Council of Scientific and Industrial Research,Government of India,New Delhi,India(CSIR)for Senior research fellowship awarded to BDK,and funding under Network Project:NWP 0010.

摘　　要：This work evaluates intercalation of Nortriptyline(NT)and Venlafaxine(VFX)in an interlayer gallery of Na^(+)-MMT(Montmorillonite),which was further compounded with Poly(LLactide)(PLLA)to form microcomposite spheres(MPs)for oral controlled drug delivery.The XRD patterns,thermal and spectroscopic analyses indicated intercalation of drugs into the MMT interlayer that was stabilized by electrostatic interaction.No significant changes in structural and functional properties of drugs were found in the MMT layers.In vitro drug release studies showed controlled release pattern.

关 键 词：NORTRIPTYLINE VENLAFAXINE Poly(L-Lactide) MONTMORILLONITE ANTIDEPRESSANT 

分 类 号：TB3[一般工业技术—材料科学与工程]