对香豆酸改善嗅球切除小鼠抑郁样行为及其AMPA受体机制  

Effect of p-coumaric acid on olfactory bulbectomy induced depression-like behaviors and its AMPA receptor mechanism in mice

作　　者：肖煦晖 李惠蓉 肖志勇[3] 李金成[1] 肖楚丽[1,2] XIAO Xu-hui;LI Hui-rong;XIAO Zhi-yong;LI Jin-cheng;XIAO Chu-li(Basic Medical School,Shaoyang University;Hunan Engineering Research Center for the Development and Utilization of Traditional Chinese Medicine in Southwest of Hunan,Shaoyang,Hunan 422000,China;the First Affiliated Hospital,University of South China,Hengyang,Hunan 421001,China)

机构地区：[1]邵阳学院基础医学院 [2]湘西南中药开发利用湖南省工程研究中心,湖南邵阳422000 [3]南华大学附属第一医院,湖南衡阳421001

出　　处：《中国药理学通报》2021年第8期1099-1103,共5页Chinese Pharmacological Bulletin

基　　金：湖南省自然科学基金资助项目(No 2019JJ50548)。

摘　　要：目的探索对香豆酸(p-coumaric acid,p-CA)对嗅球切除小鼠抑郁样行为的作用及其可能机制。方法采用嗅球摘除术建立小鼠嗅球切除(olfactory bulbectomy,OBX)模型,分别采用旷场测试观察小鼠活动度,强迫游泳测试和悬尾测试检测小鼠抑郁样行为。结果OBX小鼠强迫游泳和悬尾测试中抑郁样行为及旷场测试中激越行为显著性增加,而p-CA改善了OBX小鼠强迫游泳和悬尾测试中的抑郁样行为及旷场测试中的激越行为。此外,AMPA受体拮抗剂NBQX处理阻断了p-CA的这种改善作用,AMPA受体激动剂CX546处理增强了p-CA的这种改善作用。结论P-CA改善OBX小鼠抑郁样行为,AMPA受体可能介导了此作用。Aim To investigated the effect of p-CA on depression-like behaviors of mice of olfactory bulbectomy and its possible mechanism.Methods The olfactory bulbectomy(OBX)model of mice was established by an operation of olfactory bulbectomy.The behaviors of the mice were detected by the forced swimming test and the tail suspension test.Results The depression-like behavior in the forced swimming and tail suspension test and the in the open field test significantly increased in OBX mice;however,p-CA improved the depression-like behavior in the forced swimming and tail suspension test and the hyper-locomotor activity in open field test in OBX mice.Moreover,treatment with AMPA receptor antagonist NBQX blocked this improving effect of p-CA.While,treatment with AMPA receptor agonist CX546 enhanced this improving effect of p-CA.Conclusions P-CA improves depression-like behaviors of OBX mice,and AMPA receptors may mediate this effect.

关 键 词：对香豆酸 嗅球切除 抑郁行为 AMPA受体 AMPA受体激动剂(CX546) AMPA受体拮抗剂(NBQX) 

分 类 号：R-332[医药卫生] R338.3