幽门螺旋杆菌感染与胃间质瘤相关危险因素的相关性研究  

Analysis of the relationship between H.pylori infection and the rish factors of Gastric stromal tumors(GSTs)

作　　者：吴湛彬 周荣佳 林树洪 陈浩军 WU Zhan-bin;ZHOU Rong-jia;LIN Shu-hong;CHEN Hao-jun.(The Thrid Department of Digestion Center, Panyu Central Hospital, Guangzhou 511400)

机构地区：[1]广州市番禺区中心医院消化内科,511400

出　　处：《现代消化及介入诊疗》2021年第6期685-688,共4页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：广东省科技计划项目(2015A030302085);广东省科技计划项目(2016A020212022)。

摘　　要：目的探讨幽门螺旋杆菌(H.pylori)感染与胃间质瘤(GSTs)临床病理特征的关系。方法选取2020年1月8至2021年4月2日广州市番禺区中心医院就诊的40例GSTs患者,通过临床症状、肉眼观察、病理学及免疫组化等方法判断GSTs的部位、危险程度、起源部位、细胞异型程度、瘤体内坏死、瘤体破裂出血、瘤体最大直径等,并研究H.pylori感染与上述因素是否存在一定的相关性,以验证H.pylori感染是否增加GSTs的危险性。结果根据本实验所收集的标本中有19例H.pylori提示阳性,肿瘤的危险程度(χ^(2)=9.097、P=0.028)、瘤体破裂出血(χ^(2)=8.827、P=0.003)、瘤体的大小(χ^(2)=4.945、P=0.026)、年龄(χ^(2)=4.821、P=0.028)与H.pylori感染表现出相关性,差异均有统计学意义(P<0.05)。在H.pylori感染下能显著明显增加瘤体破裂出血的风险(χ^(2)=9.600、P=0.002)。结论H.pylori感染能够增加黏膜下层GSTs的出血风险,同时还可能增加GSTs的危险程度。这一结果对临床的工作有指导性意义。Objective To investigate the relationship between H.pylori infection and clinicopathological characteristics of Gastric stromal tumors(GSTs).We hope to discover the relationship between the GSTs occurrence and development with the H.pylori.Methods From January 2020,8 to April 2,2021,we selection 40 patients who has got diagnosed GSTs in Guangzhou Panyu Central Hospital.Through clinical symptoms,observation by naked eye,pathology and immunohistochemical method to assess the GSTs’region,degree of danger,site of origin,degree of the cellular atypia,ecrosis of the tumor,ruptures and bleeds,maximum diameter of the tumor.To research the correlation between H.pylori infection and the above factors,H.pylori infection increases the risk of GSTs.Results 19 patients with GSTs were selected to detect H.pylori infection.The risk degree of tumor(χ^(2)=9.097,P=0.028),bleeding(χ^(2)=8.827,P=0.003),tumor size(χ^(2)=4.945,P=0.026),age(χ^(2)=4.821,P=0.028)were correlated with H.pylori infection.H.pylori significantly increased the risk of GSTs bleeding(χ^(2)=9.600,P=0.002).Conclusion H.pylori infection increased the risk of bleeding in submucosal stromal tumors and increased the risk of GSTs.This result has directive function for the clinical.

关 键 词：GSTS 幽门螺旋杆菌 危险因素 微环境 临床治疗 

分 类 号：R573.9[医药卫生—消化系统]