The Hsp90-binding immunophilin FKBP52 enhances neurodifferentiation and neuroregeneration in murine models  

作　　者：Cristina Daneri-Becerra Mario D.Galigniana 

机构地区：[1]Instituto de Biología y Medicina Experimental/CONICET&Departamento de Química Biológica Facultad de Ciencias Exactas y Naturales,Universidad de Buenos Aires,Buenos Aires,Argentina

出　　处：《Neural Regeneration Research》2022年第3期555-556,共2页中国神经再生研究（英文版）

基　　金：supported in part by grants from the Universidad de Buenos Aires,No.UBACYT 20020170100558BA;Agencia Nacional de Promoción Científica y Tecnológica,No.PICT 2016-0545 and PICT 2018-0546 (all to MDG)。

摘　　要：The term immunophilin involves a family of proteins whose domain shows peptidylprolyl-(cis/trans)-isomerase (PPIase)enzymatic activity,i.e., the reversible cis/trans interconversion of Xaa-Pro bonds (Annett et al.,2020).The PPlase domain of these proteins usually binds to immunosuppressive drugs,such as the macrolide FK506 (referred to as the FKBP subfamily) or the cyclic undecapeptide cyclosporine A (called CyP subfamily).

关 键 词：BONDS REVERSIBLE ENZYMATIC 

分 类 号：R741[医药卫生—神经病学与精神病学]