Lesion-induced changes of brevican expression in the perineuronal net of the superior vestibular nucleus  

作　　者：Agnes Magyar Eva Racz Clara Matesz Ervin Wolf Peter Kiss Botond Gaal 

机构地区：[1]Pediatrics Clinic,Faculty of Medicine,University of Debrecen,Debrecen,Hungary [2]Department of Anatomy,Histology and Embryology,Faculty of Medicine,University of Debrecen,Debrecen,Hungary [3]Division of Oral Anatomy,Faculty of Dentistry,University of Debrecen,Debrecen,Hungary [4]MTA-DE Neuroscience Research Group,Debrecen,Hungary

出　　处：《Neural Regeneration Research》2022年第3期649-654,共6页中国神经再生研究（英文版）

基　　金：supported by the Hungarian Academy of Sciences–Office for Supported Research Groups:MTA-TKI 355;University of Debrecen–Medical and Health Sciences Center Bridging Fund;Hungarian Scientific Research Fund K115471.Obtained by Clara Matesz and colleagues。

摘　　要：Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements,posture and vegetative functions.After a shorter or longer period of time,the vestibular function is partially or completely restored via a series of processes such as modification in the efficacy of synaptic inputs.As the plasticity of adult central nervous system is associated with the alteration of extracellular matrix,including its condensed form,the perineuronal net,we studied the changes of brevican expression in the perineuronal nets of the superior vestibular nucleus after unilateral labyrinth lesion.Our results demonstrated that the unilateral labyrinth lesion and subsequent compensation are accompanied by the changing of brevican staining pattern in the perineuronal nets of superior vestibular nucleus of the rat.The reduction of brevican in the perineuronal nets of superior vestibular nucleus may contribute to the vestibular plasticity by suspending the non-permissive role of brevican in the restoration of perineuronal net assembly.After a transitory decrease,the brevican expression restored to the control level parallel to the partial restoration of impaired vestibular function.The bilateral changing in the brevican expression supports the involvement of commissural vestibular fibers in the vestibular compensation.All experimental procedures were approved by the 'University of Debrecen–Committee of Animal Welfare'(approval No.6/2017/DEMAB) and the 'Scientific Ethics Committee of Animal Experimentation'(approval No.HB/06/éLB/2270-10/2017;approved on June 6,2017).

关 键 词：BRAINSTEM BREVICAN chondroitin sulfate proteoglycan extracellular matrix labyrinth lesion neural plasticity perineuronal net perisynaptic matrix vestibular compensation vestibular system 

分 类 号：R446[医药卫生—诊断学] R364[医药卫生—临床医学]