晚期宫颈癌患者术后使用新辅助化疗模式对临床病情和血清相关因子的影响  

Effect of neoadjuvant chemotherapy after surgery on clinical condition and serum factors in patients with advanced cervical cancer

作　　者：杨益[1] 许永萍[1] 陈刚 YANG Yi;XU Yong-Ping;CHEN Gang(Department of Oncology,Coast Guard Corps Hospital of the Chinese People's Armed Police Force,Jiaxing,Zhejiang 314000,China)

机构地区：[1]中国人民武装警察部队海警总队医院肿瘤科,浙江嘉兴314000

出　　处：《中国妇幼保健》2021年第13期2937-2940,共4页Maternal and Child Health Care of China

基　　金：浙江省嘉兴市科技计划项目(2018AD32182)。

摘　　要：目的分析晚期宫颈癌患者术后使用新辅助化疗模式对患者的临床病情和血清相关因子的影响。方法选取2018年3月-2019年3月于中国人民武装警察部队海警总队医院进行治疗的晚期宫颈癌患者74例,所有患者均采用手术方法进行治疗,随机将患者分为观察组(采用新辅助化疗模式干预术后恢复)和对照组(采用常规治疗干预术后恢复)各37例,观察比对两组患者干预结束后其临床病情和血清相关因子情况。结果干预前两组患者的平均肿瘤直径、血清VEGF水平差异无统计学意义(P>0.05);干预后观察组患者的平均肿瘤直径、血清VEGF、TNF-α、NF-κB水平及生活质量评分均较对照组患者更佳,并发症发生率少于对照组患者,两组差异均有统计学意义(P<0.05)。结论对晚期宫颈癌患者术后使用新辅助化疗模式干预可显著提升患者的整体治疗效果,降低术后血清VEGF、TNF-α、NF-κB水平及肿瘤直径,并且有效改善患者的并发症发生率与生活质量情况,整体治疗效果明显,是一种值得临床大力推广使用的干预方法。Objective To analyze the effect of neoadjuvant chemotherapy after surgery on clinical condition and serum factors in patients with advanced cervical cancer. Methods A total of 74 patients with advanced cervical cancer treated in Coast Guard Corps Hospital of the Chinese People’s Armed Police Force from March 2018 to March 2019 were selected,all the patients were treated by surgery,then they were randomly divided into observation group(37 cases treated with neoadjuvant chemotherapy to intervene postoperative recovery) and control group(37 cases treated with conventional treatment to intervene postoperative recovery). The clinical conditions and serum factors after intervention in the two groups were observed and compared. Results There was no statistically significant difference in average tumor diameter and serum VEGF level before intervention between the two groups(P>0. 05). After intervention,the average tumor diameter,serum VEGF,TNF-α,NF-κB levels,and score of life quality in observation group were statistically significantly better than those in control group,the incidence rate of complications in observation group was statistically significantly less than that in control group(P<0. 05). Conclusion Neoadjuvant chemotherapy after surgery can significantly improve the overall treatment effect of patients with advanced cervical cancer,reduce the levels of serum VEGF,TNF-α,NF-κB,and tumor diameter after surgery,and effectively improve the incidence rate of complications and quality of life of patients. The overall treatment effect is obvious,which is an intervention method worthy of clinical promotion.

关 键 词：新辅助化疗模式 晚期宫颈癌 血清因子 

分 类 号：R737.33[医药卫生—肿瘤]