共价有机框架的合成及其在肿瘤治疗中的应用研究进展  

Research Progress on the Synthesis of Covalent Organic Frameworks and Their Applications in Tumor Therapy

作　　者：王涛 赵璐[1] 王科伟[1] 白云峰[1] 冯锋[1] Tao Wang;Lu Zhao;Kewei Wang;Yunfeng Bai;Feng Feng(College of Chemistry and Chemical Engineering,Shanxi Provincial Key Laboratory of Chemical Biosensing,Shanxi Datong University,Datong 037009,China)

机构地区：[1]山西大同大学化学与化工学院化学生物传感山西省重点实验室,大同037009

出　　处：《化学学报》2021年第5期600-613,共14页Acta Chimica Sinica

基　　金：国家自然科学基金(No.21975146);山西省自然科学基金(No.201801D121035);山西省高等学校科学研究优秀成果培育项目(No.2020KJ023);山西省省筹资金资助回国留学人员科研项目(No.2020-133)资助.

摘　　要：共价有机框架(covalent organic frameworks,COFs)是近年来开发的一种由有机单元连接而成的高结晶性多孔聚合物,由于具有良好的孔隙率、模块性、结晶性和生物相容性等特点在肿瘤治疗中显示出了良好的应用前景.本综述总结了已报道的COFs制备方法,包括溶剂热合成法、机械化学合成法、微波合成法、离子热合成法、界面合成法、室温合成法和纳米尺度COFs的合成方法,并根据对肿瘤作用机理的差异,将用于肿瘤治疗的COFs纳米载药系统归纳为药物化疗、光热治疗、光动力学治疗和联合治疗.此外还讨论了COFs在肿瘤治疗领域所面临的主要挑战和发展趋势.Covalent organic frameworks(COFs)are a class of crystalline porous polymer composed of organic units devel-oped in recent years.Due to their good porosity,modularity,crystallinity and biocompatibility,they show a good application prospect in tumor therapy.The porous channels with adjustable pore sizes of COFs make them become an ideal drug delivery material.In addition,COFs can also be used in photothermal therapy and photodynamic therapy in combination with photo-thermal agents and photosensitizers.This review systematically introduces the synthesis methods of COFs,including sol-vothermal synthesis,mechanochemical synthesis,microwave synthesis,ionothermal synthesis,interfacial synthesis,room temperature synthesis and nanoscale synthesis.According to the differences in the mechanism of tumor therapy,the applica-tions of COFs nanocarrier system for tumor therapy were reviewed,including chemotherapy,photothermal therapy,photo-dynamic therapy and combined therapy,proving that the promising drug carrier can effectively improve the therapeutic effect of nanocarriers on tumors.In addition,the main challenges and development trends of the COFs in the field of tumor therapy are discussed.This review could inspire research to design more effective COFs nano-drug delivery systems and promote the development of tumor therapy.

关 键 词：共价有机框架 纳米材料 肿瘤治疗 药物载体 

分 类 号：TQ317[化学工程—高聚物工业] R730.5[医药卫生—肿瘤]