中医外治法对炎性肠病的免疫调节机制研究进展  

Research progress on immune regulation mechanism of external therapy of traditional Chinese medicine on inflammatory bowel disease

作　　者：焦谊 张英琦 鲁梦倩[1] 于天源[1] 刘志凤 刘迪[2] JIAO Yi;ZHANG Yingqi;LU Mengqian;YU Tianyuan;LIU Zhifeng;LIU Di(School of Acupuncture and Moxibustion and Massage,Beijing University of Chinese Medicine,Beijing100029,China;Department of Acupuncture and Moxibustion,Oriental Hospital of Beijing University of Chinese Medicine,Beijing100078,China)

机构地区：[1]北京中医药大学针灸推拿学院,北京100029 [2]北京中医药大学东方医院针灸科,北京100078

出　　处：《中国医药导报》2021年第21期38-41,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81704193)。

摘　　要：炎性肠病(IBD)是一种病变部位在结肠和直肠黏膜的自身免疫性疾病,目前认为IBD多与饮食、情志、感染、免疫相关,其中对免疫的研究最多,临床多选取针刺、艾灸、推拿、中药灌肠疗法4种中医外治法。本文从IBD的炎症免疫角度,探讨中医外治法对IBD的免疫调节机制。中医外治法通过多靶点、多通路调节机体炎症免疫反应,达到正气存内,邪不可干的状态。本文涉及的4种外治法干预方式不同,涉及的机制也有差异,针刺予以机械刺激,艾灸予以温热刺激,推拿同时予以机械刺激和温热刺激,中药灌肠疗法予以药物刺激。针刺和艾灸都涉及平衡免疫微环境及抗炎机制,针刺还涉及抗氧化应激反应、抗内质网应激反应和缓解内脏敏感性,推拿主要提供了充足的形态学依据,中药灌肠疗法通过直接接触病变部位调节免疫紊乱。Inflammatory bowel disease(IBD)is an autoimmune disease with lesions located in the mucosa of colon and rectum.At present,IBD is believed to be mostly related to diet,mood,infection and immunity,among which immunity is the most studied.Four traditional Chinese medicine external treatment methods are mostly selected clinically,including acupuncture,moxa-wool moxibustion,massage and traditional Chinese medicine enema therapy.In this paper,from the point of inflammation and immunity of IBD,the immune regulation mechanism of external treatment of Chinese medicine on IBD is discussed.The external treatment of traditional Chinese medicine can regulate the inflammatory immune response of the body through multiple targets and channels,so as to achieve the state that the vital qi is stored inside and the pathogen cannot be dried.The four kinds of external therapy intervention methods involved in this paper are different,and the mechanisms involved are also different.Acupuncture provides mechanical stimulation,moxa-wool moxibustion provides warm stimulation,and massage provides both mechanical stimulation and warm stimulation,and traditional Chinese medicine enema therapy provides drug stimulation.Acupuncture and moxa-wool moxibustion are both involved in balancing immune microenvironment and anti-inflammatory mechanism.Acupuncture is also involved in anti-oxidative stress response,anti-endoplasmic reticulum stress response and the alleviation of visceral sensitivity.Massage mainly provides sufficient morphological basis,and traditional Chinese medicine enema therapy regulates immune disorders through direct contact with the lesion site.

关 键 词：中医外治法 针刺 艾灸 推拿 中药灌肠疗法 炎症免疫反应 炎性肠病 

分 类 号：R574.6[医药卫生—消化系统]