卵巢恶性生殖细胞肿瘤保留生育功能治疗后的内分泌及生育功能变化的meta分析  

Meta analysis of the changes of endocrine and fertility function after fertility-sparing treatment for malignant ovarian germ cell tumors

作　　者：胡明淼 陈梦捷 梁月娟 王鹤[2] HU Mingmiao;CHEN Mengjie;LIANG Yuejuan;WANG He(Department of Gynecology,Wuming Hospital of Guangxi Medical University,Guangxi Zhuang Autonomous Region,Nanning 530199,China;Department of Gynecology Tumor,Affiliated Tumor Hospital of Guangxi Medical University,Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]广西医科大学附属武鸣医院妇科,广西南宁530199 [2]广西医科大学附属肿瘤医院妇瘤科,广西南宁530021

出　　处：《中国医药导报》2021年第21期96-100,共5页China Medical Herald

基　　金：国家重点研发计划课题(2016YFC1303702)。

摘　　要：目的系统评价卵巢恶性生殖细胞肿瘤保留生育功能治疗后患者的内分泌及生育功能变化情况。方法计算机检索PubMed、EMbase、知网、万方等数据库的所有涉及卵巢恶性生殖细胞肿瘤保留生育功能治疗后的月经及生育变化相关文献,搜索时间为建库至2021年1月。采用主题词、关键词相结合的方法进行检索。采用R3.6.1软件进行数据分析。结果最终纳入13篇文献,727例患者。meta分析结果显示,卵巢恶性生殖细胞肿瘤保留生育功能治疗后患者的合并妊娠率为88%(95%CI:84%~92%)、合并月经正常率为90%(95%CI:85%~95%)。均未发现有致畸、致残及对智力的负面影响记录。结论卵巢恶性生殖细胞肿瘤保留生育功能治疗对卵巢功能影响较小,目前未发现对月经及生育功能产生持续性影响。Objective To systematically evaluate the changes of endocrine and fertility function after fertility-sparing treatment for malignant ovarian germ cell tumors.Methods Literatures related to menstruation and fertility changes after fertility-sparing treatment for malignant ovarian germ cell tumors were searched in PubMed,EMbase,CNKI,Wanfang and other databases by computer.The search time was from the establishment of the database to January 2021.The method of combining subject words and key words was used to search.R3.6.1 software was used for data analysis.Results Finally,13 articles involving 727 patients were included.Meta analysis results showed that,the complication rate of pregnancy was 88%(95%CI:84%-92%)and the complication rate of normal menstruation was 90%(95%CI:85%-95%)after fertility-sparing treatment for malignant ovarian germ cell tumor.Conclusion Fertility-sparing treatment for malignant ovarian germ cell tumors has little effect on ovarian function,and no lasting effect on menstruation and fertility function has been found at present.

关 键 词：卵巢恶性生殖细胞肿瘤 保留生育功能 月经 META分析 

分 类 号：R737.31[医药卫生—肿瘤]