结节性多动脉炎发病机制解析  

Pathogenesis of polyarteritis nodosa

作　　者：付敏 秦蕾 王慧杰 夏光涛 FU Min;QIN Lei;WANG Huijie;XIA Guangtao(Department of Rheumatology and Immunology,Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,Shandong Province,China)

机构地区：[1]山东第一医科大学附属省立医院风湿免疫科,山东济南250021

出　　处：《世界临床药物》2021年第6期429-432,共4页World Clinical Drug

基　　金：国家自然科学基金(82001744);山东省重点研发项目(2017GSF218083);济南市临床医学科技创新计划(202019051)。

摘　　要：结节性多动脉炎(polyarteritis nodosa,PAN)作为一类累及中、小动脉全层的坏死性血管炎(necrotizing vasculitis),其发病机制尚不明确,存在病程长、诊断困难的问题,导致患者病情无法及时得到有效控制,最终可能发生重要脏器受侵,严重影响其生活质量,甚至威胁生命。本文结合既往研究,围绕PAN发病机制研究进展作一综述,旨在为临床诊治提供一定参考。Polyarteritis nodosa(PAN) is a kind of necrotizing vasculitis involving the whole layer of the middle and small arteries.Its pathogenesis is not clear,and it has the problems of long course and difficult diagnosis.As a result,the patient’s condition can not be effectively controlled in time,and eventually the invasion of important organs may occur,which seriously affects the quality of life,even life-threatening.In this paper,we reviewed the research progress on the pathogenesis of PAN in order to provide some reference for clinical diagnosis and treatment.

关 键 词：结节性多动脉炎 坏死性血管炎 发病机制 

分 类 号：R543.5[医药卫生—心血管疾病]