Clinical characteristics and post-discharge follow-up analyses of 10 infants with congenital tuberculosis:A retrospective observational study  

作　　者：Juan Du Shixiao Dong Shengnan Jia Qiaoru Zhang Mingyan Hei 

机构地区：[1]Neonatal Center,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing,China

出　　处：《Pediatric Investigation》2021年第2期86-93,共8页儿科学研究（英文）

基　　金：This study was supported by the Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority(No.XTCX201816);We thank pediatric TB specialist Dr.Shunying Zhao and her team for the consultation of all patients.We also gratefully acknowledge imaging analysis support from experienced radiologists.

摘　　要：Importance Congenital tuberculosis(TB)is a rare,potentially fatal disease.There is currently a lack of detailed clinical information available regarding this disease.Objective This retrospective study investigated the clinical manifestations,treatment,and long-term prognosis of congenital TB.Methods Patients were treated in Beijing Children’s Hospital,Capital Medical University(Beijing,China)between 2009 and 2018.Their demographic data,maternal and family histories,symptoms and signs,treatment information,and follow-up data were retrospectively collected using the hospital’s electronic information system.Results Ten infants with congenital TB were enrolled.The mean gestational age was 36.6±2.2 weeks and mean birth weight was 2517±487 g.All 10 patients exhibited fever,nine patients(90%)had anemia,and six patients(60%)had extrauterine growth retardation.On chest computed tomography scans,all 10 patients presented multiple pulmonary nodules and four patients(40%)had mediastinal adenopathy.Nine out of ten(90%)completed the T-spot test,and eight of them(8/9,89%)were positive.Anti-TB treatment was initiated upon diagnostic confirmation.All patients(100%)received combined treatment with isoniazid(INH)and rifampicin(RIF).Eight of 10 patients(80%)received combined treatment with INH,RIF,and pyrazinamide.The survival rate was 100%.One patient was lost to follow-up and four patients are currently continuing treatment.Three of nine patients(33%)achieved normal developmental milestones at 6 months of age.Interpretation Early diagnosis based on maternal history,typical imaging results,and timely treatment can improve outcomes in infants with congenital TB.

关 键 词：Congenital tuberculosis INFANT NEWBORN LINEZOLID FOLLOW-UP 

分 类 号：R725.1[医药卫生—儿科]