Plasma exchange therapy for acute necrotizing encephalopathy of childhood  

作　　者：Kechun Li Tao Zhang Gang Liu Ping Jin Yeqing Wang Lijie Wang Meixian Xu Chunyi Liu Yingchao Liu Tao Zhou Yan Xu Ying Yang Boliang Fang Xin Yang Chunfeng Liu Suyun Qian 

机构地区：[1]Department of Pediatric Intensive Care Unit,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,China [2]Department of Pediatrics,Shengjing Hospital of China Medical University,Shenyang,Liaoning,China [3]Department of Pediatric Intensive Care Unit,Hebei Children's Hospital,Hebei Medical University,Shijiazhuang,Hebei,China [4]Department of Pediatric Intensive Care Unit,Bao'an Maternity&Child Health Hospital,Shenzhen,Guangdong,China [5]Research Unit of Critical infection in Children,Chinese Academy of Medical Sciences,2019RU016

出　　处：《Pediatric Investigation》2021年第2期99-105,共7页儿科学研究（英文）

基　　金：This study was supported by Capital’s Funds for Health Improvement and Research of Beijing Children’s Hospital,Capital Medical University(No.2020-2-2094);the CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5-026);We would like to thank all the families and individuals who participated in this study,and appreciate all the staffs in the PICU from the four centers.

摘　　要：Importance Acute necrotizing encephalopathy(ANE)is a rare disease with high mortality.Plasma exchange(PLEX)has recently been reported to treat ANE of childhood(ANEC),but its efficacy is uncertain.Objective This study aimed to investigate the effectiveness of PLEX on ANEC.Methods A retrospective study was conducted in four pediatric intensive care units from December 2014 to December 2020.All patients who were diagnosed with ANEC were included;however,these patients were excluded if their length of stay was less than 24 h.Participants were classified into PLEX and non-PLEX groups.Results Twenty-nine patients with ANEC were identified,10 in the PLEX group and 19 in the non-PLEX group.In the PLEX group,C-reactive protein,procalcitonin,alanine aminotransferase,and aspartate aminotransaminase levels were significantly lower after 3 days of treatment than before treatment(13.1 vs.8.0,P=0.043;9.8 vs.1.5,P=0.028;133.4 vs.31.9,P=0.028;282.4 vs.50.5,P=0.046,respectively).Nine patients(31.0%,9/29)died at discharge,and a significantly difference was found between the PLEX group and non-PLEX group[0 vs.47.4%(9/19),P=0.011].The median follow-up period was 27 months,and three patients were lost to follow-up.Thirteen patients(50.0%,13/26)died at the last follow-up,comprising three(33.3%,3/9)in the PLEX group and ten(58.8%,10/17)in the non-PLEX group,but there was no significant difference between the two groups(P=0.411).Three patients(10.3%,3/29)fully recovered.Interpretation PLEX may reduce serum C-reactive protein and procalcitonin levels and improve liver function in the short term.PLEX may improve the prognosis of ANEC,and further studies are needed.

关 键 词：Acute necrotizing encephalopathy CHILDREN Plasma exchange PROGNOSIS 

分 类 号：R742[医药卫生—神经病学与精神病学]