脱氧核糖核苷三磷酸池稳定性在肿瘤发生、发展中的作用  

Role of the stability of deoxyribonucleoside triphosphate pool in the development and progression of tumors

作　　者：喻玮[1] 张家杰[2] 张丽[1] 裘云庆[1] Yu Wei;Zhang Jiajie;Zhang Li;Qiu Yunqing(Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China;Department of Infectious Diseases,Zhejiang Provincial People's Hospital,People's Hospital of Hangzhou Medical College,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第一医院传染病诊治国家重点实验室国家感染性疾病临床研究中心感染性疾病诊治协同创新中心浙江省药物临床研究与技术重点实验室,杭州310003 [2]浙江省人民医院杭州医学院附属人民医院感染病科,杭州310003

出　　处：《肿瘤研究与临床》2021年第6期460-464,共5页Cancer Research and Clinic

基　　金：浙江省医药卫生科技计划面上项目(2020KY409)。

摘　　要：脱氧核糖核苷三磷酸(dNTP)池稳定性对于合成正常核和线粒体DNA必不可少。任何一种dNTP的缺乏或过量都可能造成DNA损伤,增加突变率,并导致基因组不稳定。目前研究已证实dNTP池不稳定与多种肿瘤发生密切相关,且其通过多种途径参与肿瘤的发展,但dNTP池稳定性失衡导致肿瘤的作用机制十分复杂。文章就维持dNTP池稳定性及其与DNA损伤修复的关系进行阐述,以期为肿瘤的早期诊断和靶向治疗提供理论基础。The stability of deoxyribonucleoside triphosphate(dNTP)pool is essential for the normal synthesis of nuclear and mitochondrial DNA.The lack or excess of any dNTP may cause DNA damage and genomic instability,and increase mutation rate.Present studies have confirmed that the instability of dNTP pool is closely related to a variety of tumorigenesis.In addition,dNTP pool is involved in the development of tumor via multiple pathways,while the mechanisms of tumors caused by the instability of dNTP are complicated.This paper discusses the relationship between the stability of dNTP pool and DNA damage repair to provide a theoretical basis for early diagnosis and targeted treatment of tumors.

关 键 词：细胞周期 DNA损伤 基因组稳定性 核苷类似物 

分 类 号：R730.2[医药卫生—肿瘤]