多聚腺苷酸结合蛋白相互作用蛋白1与肿瘤关系的研究进展  

Research progress on the relationship between Poly(A)-binding protein-interacting protein 1 and tumor

作　　者：罗胜茂 易世江[2] 凌月福[2] LUO Shengmao;YI Shijiang;LING Yuefu(Guilin Medical University,Guangxi Guilin 541004,China;Department of Otolaryngology-Head and Neck Surgery,Affiliated Hospital of Guilin Medical University,Guangxi Guilin 541004,China.)

机构地区：[1]桂林医学院,广西桂林541004 [2]桂林医学院附属医院耳鼻咽喉头颈外科,广西桂林541004

出　　处：《现代肿瘤医学》2021年第16期2918-2922,共5页Journal of Modern Oncology

基　　金：广西桂林市科学研究与技术开发项目(编号:20150206-1-6)。

摘　　要：多聚腺苷酸结合蛋白相互作用蛋白1[Poly(A)-binding protein-interacting protein 1,Paip1]是哺乳动物特有的蛋白质,可有效参与真核生物基因表达及细胞周期调控,并与肿瘤演进及预后密切相关。近年来Paip1成为肿瘤研究热点,Paip1与肿瘤细胞增殖、迁移、侵袭和上皮间质转化进程密切相关,可能是肿瘤进展及预后不良的潜在生物标志和新的治疗靶点。但其具体作用机制尚未阐明。本文就Paip1的结构、功能、泛素化和降解及其与肿瘤的关系等方面作一综述,为其在肿瘤中的研究提供新思路。As a specific mammalian protein,Poly(A)-binding protein-interacting protein 1(Paip1)can take effective part in eukaryotic gene expression and cell cycle regulation,and is closely related to tumor evolution and prognosis.Human Paip1 has become a research hotspot in recent years,mainly in the field of cancer.Existing research shows that Paip1 is correlated to tumor proliferation,migration,invasion and epithelial mesenchymal transformation,which could be potential biomarkers and new therapeutic targets for a variety of tumors with poor prognosis.However,there is no consensus on its specific mechanism.This review aims to provide a more comprehensive understanding of the structure,function,ubiquitination and degradation of Paip1 as well as its relationship with tumors,and then provide new ideas for the treatment and prognosis evaluation of some tumors.

关 键 词：多聚腺苷酸结合蛋白相互作用蛋白1 信号通路 基因表达调控 细胞周期 肿瘤 

分 类 号：R730[医药卫生—肿瘤]