二烯丙基三硫化物抗肿瘤作用机制的研究进展  

Advances in the regulation of diallyl trisulfide on tumor

作　　者：唐勤彩 黄益玲 罗和生[2] TANG Qincai;HUANG Yiling;LUO Hesheng(Department of Pathology,Medical College of China Three Gorges University,Hubei Yichang 443002,China;Department of Gastroenterology,Renmin Hospital of Wuhan University,Hubei Wuhan 430060,China.)

机构地区：[1]三峡大学医学院病理学系,湖北宜昌443002 [2]武汉大学人民医院消化内科,湖北武汉430060

出　　处：《现代肿瘤医学》2021年第16期2932-2936,共5页Journal of Modern Oncology

基　　金：湖北省教育厅中青年人才项目(编号:Q20191209)。

摘　　要：二烯丙基三硫化物(diallyl trisulfide,DATS)是大蒜素的主要分解产物和活性成分之一。研究发现DATS具有抗肿瘤、抑菌、抗氧化应激及参与炎症反应调节等多种生物学效应。DATS能够通过多种途径抑制肿瘤细胞增殖、侵袭和迁移,其作用机制包括细胞周期阻滞、诱导细胞凋亡、调节氧化应激及参与肿瘤免疫等。本文就近年来国内外研究DATS抗肿瘤效应的文献进行回顾和综述。Diallyl trisulfide(DATS)is one of the main decomposition products and active components of allicin.DATS has several biological effects,such as anti-tumor,bacteriostasis,anti-oxidative stress and involved in the regulation of inflammatory response.DATS can inhibit the proliferation,invasion and migration of tumor cells through several mechanisms,including cell cycle arrest,apoptosis induction,oxidative stress and tumor immunity regulation.The literatures about the antitumor effect of DATS at home and abroad were reviewed in this paper.

关 键 词：二烯丙基三硫化物 肿瘤 细胞凋亡 细胞周期阻滞 

分 类 号：R73-36[医药卫生—肿瘤]