中药注射液治疗食管癌作用研究进展  

Chinese Medicine Injections in Treatment of Esophageal Cancer:A Review

作　　者：赵雯宇 司富春[1] 王文彬 宋雪杰[1] 杨晖[1] ZHAO Wen-yu;SI Fu-chun;WANG Wen-bin;SONG Xue-jie;YANG Hui(Henan Provincial Key Laboratory of Prescription-Syndrome Signal Transduction of Chinese Medicine/International Joint Laboratory of Prescription-Syndrome Signal Transduction of Chinese Medicine in Henan Province,College of Chinese Medicine(Zhongjing College),Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学,河南省中医方证信号传导重点实验室/河南省中医方证信号传导国际联合实验室,中医学院(仲景学院),郑州450046

出　　处：《中国实验方剂学杂志》2021年第15期227-234,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家博士后基金项目(2016T90669)。

摘　　要：食管癌发病率和死亡率位居全球前列,我国食管癌疾病负担繁重,放化疗等常规治疗方法疗效欠佳,大部分食管癌患者不能得到安全有效的治疗。目前,食管癌的临床治疗以中医药联合放化疗的综合治疗为主。经过中英文文献检索,康艾注射液、复方苦参注射液、康莱特注射液、消癌平注射液、艾迪注射液、鸦胆子油乳、华蟾素注射液和参麦注射液是临床常用抗食管癌中药注射液,此8种中药注射液为单味中药制剂或多味中药复方制剂,共涉及到11味中药,在联合放化疗治疗食管癌过程中起到了显著的增效减毒作用。由于中药成分的复杂性,注射液在使用中因为不合理的用药剂量、给药速度、药物配伍等原因亦会引发一系列诸如静脉炎、静脉血管硬化、溶血等的不良反应。抗食管癌中药注射液的临床研究较多,但有效成分及分子机制研究较少,该文对常用中药注射液治疗食管癌的有效成分、有效性、安全性及作用机制进行综述,以期为抗食管癌临床中药注射液的使用提供参考,也为抗食管癌中药新药研发提供思路。Esophageal cancer has a high morbidity and mortality worldwide, and the burden of esophageal cancer is still heavy in China. The conventional treatments such as radiotherapy and chemotherapy fail to yield a satisfactory outcome,implying that the safe and effective treatments are not available for the majority of patients. At present,esophageal cancer is mainly treated by Chinese medicine combined with radiotherapy and chemotherapy. The retrieval of related papers in Chinese and English reveals that Kang’ai injection,Compound Kushen injection,Kanglaite injection,Xiaoaiping injection,Aidi injection,Bruceae Fructus Oil Emulsion,Cinobufotalin injection,and Shenmai injection have been commonly used in esophageal cancer treatment. These eight injections are either single medicinal or compound preparations,involving 11 Chinese medicinals,which synergize the effects of radiotherapy and chemotherapy and reduce their adverse reactions in the treatment of esophageal cancer. Due to the complexity of Chinese medicinal components,a series of adverse reactions such as phlebitis,phlebosclerosis,and hemolysis may be caused by irrational dosage,administration speed,and compatibility in the use of injection. There are many clinical studies on Chinese medicine injections for anti-esophageal cancer but few studies on their active components and molecular mechanism. This paper reviewed the active components,effectiveness,safety,and mechanism of Chinese medicine injections frequently employed for treating esophageal cancer,in order to provide reference for their clinical application as well as the development of new Chinese drugs.

关 键 词：中药注射液 食管癌 成分 安全性 有效性 分子机制 

分 类 号：R22[医药卫生—中医基础理论] R242[医药卫生—中医学]